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Samples were collected from the root canals of 40 patients who needed endodontic retreatment and had radiographic evidence of apical periodontitis. Lipopolysaccharides (LPS) and lipoteichoic acid (LTA) were quantified using Limulus amebocyte lysate and enzyme\u2010linked immunosorbent assay tests, respectively. LPS and LTA were detected in all samples, with mean values being 5.1 EU\/mL(\u00b12.83) and 537.53\u2009pg\/mL(\u00b1134.14), respectively. Significant correlations were found between levels of LPS and LTA with clinical features. In conclusion, coronal restoration directly influences the load of LPS and LTA in root canals with secondary infection. Furthermore, higher concentrations of endotoxin (LPS) are associated with larger areas of periapical bone resorption, as well as with the presence of clinical signs and symptoms.<\/jats:p>","DOI":"10.1111\/aej.12963","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:26:02Z","timestamp":1751426762000},"page":"458-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between\n                    <scp>LPS<\/scp>\n                    and\n                    <scp>LTA<\/scp>\n                    Levels With Clinical Features in Secondary Endodontic Infections"],"prefix":"10.1111","volume":"51","author":[{"suffix":"Jr","given":"Ederaldo P.","family":"Godoi","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Ivo G.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila A.","family":"Francisco","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara\u00edsa G.","family":"Delboni","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlos","family":"Barbosa\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"},{"name":"School of Dentistry Universidade de Pernambuco \u2010 Arcoverde  Pernambuco PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos S.","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"},{"name":"Department of Dentistry, Health Sciences Center Uning\u00e1 \u2013 Ing\u00e1 University Center  Maring\u00e1 PR Brazil"},{"name":"Division of Endodontics, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry University of Maryland  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica M.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School State University of Campinas\u2010UNICAMP  Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico C.","family":"Martinho","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry University of Maryland  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-0646","authenticated-orcid":false,"given":"Brenda P. 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