{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:20:08Z","timestamp":1788574808618,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although the inflammation\u2010resolving properties of Resolvin E1 have been characterised, its effect on autophagy during pulpitis resolution remains unclear. We established a rat pulpitis model to investigate the changes in autophagy during Resolvin E1\u2010mediated pulpitis resolution. Histological staining and gene quantification were performed to assess pulp tissue injury and changes in inflammation\u2010 and autophagy\u2010related gene expression. In\u00a0vivo, Resolvin E1 promoted dental tissue repair and reduced the expression of tumour necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, and CD68 in dental pulp tissues. Resolvin E1 significantly activated LC3II and Atg12 and decreased Atg5 level. Beclin1 expression was upregulated on day 1 and downregulated on day 3. In\u00a0vitro, Resolvin E1 enhanced human dental pulp cell proliferation; reduced inflammatory marker expression; and regulated LC3II, Beclin1, Atg5, and Atg12 expression. Resolvin E1 could reduce inflammatory damage and induce autophagy response to protect dental pulp tissue.<\/jats:p>","DOI":"10.1111\/aej.12971","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:00:03Z","timestamp":1751360403000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resolvin\n                    <scp>E1<\/scp>\n                    Promotes the Resolution of Dental Pulp Inflammation and Induces Autophagy"],"prefix":"10.1111","volume":"51","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Laboratory of Dental Biomaterials and Tissue Regeneration Shanghai Xuhui District Stomatological Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Ye","sequence":"additional","affiliation":[{"name":"Laboratory of Dental Biomaterials and Tissue Regeneration Shanghai Xuhui District Stomatological Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Qian","sequence":"additional","affiliation":[{"name":"Laboratory of Dental Biomaterials and Tissue Regeneration Shanghai Xuhui District Stomatological Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4870-4311","authenticated-orcid":false,"given":"Yunbo","family":"Xing","sequence":"additional","affiliation":[{"name":"Laboratory of Dental Biomaterials and Tissue Regeneration Shanghai Xuhui District Stomatological Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01619-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.11.016"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.01.021"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108753"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.011"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4050"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02141-y"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2979"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300414"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09782"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.01.018"},{"key":"e_1_2_13_13_1","first-page":"531","article-title":"Effect of Autophagy in Dental Pulp Repair","volume":"35","author":"Chen J.","year":"2019","journal-title":"J Oral Sci Res"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114188"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653085"},{"key":"e_1_2_13_16_1","first-page":"467","article-title":"Characterization of Primary Dental Pulp Cells In\u00a0Vitro","volume":"31","author":"Coppe C.","year":"2009","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_13_17_1","first-page":"16379","article-title":"Serum Cystatin C Can Detect Impaired Graft Function Early After Renal Transplantation","volume":"8","author":"Zhou S. 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