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Ninety participants with necrotic pulp and preoperative pain (VAS \u2265\u20097) were randomised into two groups: Group A received room\u2010temperature saline irrigation, while Group B received cryotreated saline (2.5\u00b0C) as the final irrigant. Pain was assessed preoperatively, at 24\u2009h, and 48\u2009h post\u2010treatment using the Visual Analogue Scale. Results demonstrated significantly lower pain scores in the cryotherapy group at 24\u2009h (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) and 48\u2009h (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with reduced analgesic use. Cryotherapy effectively mitigates post\u2010operative pain in symptomatic apical periodontitis, offering a non\u2010invasive adjunct to standard endodontic therapy.\n                  <\/jats:p>","DOI":"10.1111\/aej.12983","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T05:58:15Z","timestamp":1753509495000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Post\u2010Endodontic Pain Reduction Using Intracanal Cryotherapy in Symptomatic Apical Periodontitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5806-7715","authenticated-orcid":false,"given":"Anam Fayyaz","family":"Bashir","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry Lahore Medical and Dental College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ussamah 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Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima Razaq","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry Lahore Medical and Dental College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences The University of Buckingham  Buckingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences The University of Buckingham  Buckingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sohail","family":"Zafar","sequence":"additional","affiliation":[{"name":"Clinical Sciences Department College of Dentistry Ajman University  Ajman UAE"},{"name":"Center of Medical and Bio\u2010Allied Health Sciences Research Ajman 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