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A total of 55 mice (28 WT, 27 TLR2\u2010KO) underwent pulpal exposure of mandibular first molars and were euthanised at 7, 21, or 42\u2009days post\u2010exposure. Histological and immunohistochemical analyses were performed. TLR2\u2010KO mice showed significantly larger periapical lesions and higher IL\u20101\u03b2 expression than WT mice after 21 and 42\u2009days, respectively. In contrast, NLRP3 expression was significantly greater in WT mice at both time points. A weak but significant positive correlation between NLRP3 and IL\u20101\u03b2 expression was observed only in WT mice. These findings suggest that TLR2 plays a protective role in limiting periapical bone resorption and modulating inflammatory cytokine expression, independent of NLRP3 inflammasome activity.<\/jats:p>","DOI":"10.1111\/aej.70014","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:00:54Z","timestamp":1756364454000},"page":"748-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Evaluation of\n                    <scp>NLRP3<\/scp>\n                    Inflammasome and\n                    <scp>IL<\/scp>\n                    \u20101\u03b2 Cytokine in Periapical Lesion Progression Using Wild\u2010Type and\n                    <scp>TLR2<\/scp>\n                    Knockout Mice"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6462-5233","authenticated-orcid":false,"given":"Gabriela 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