{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:57:36Z","timestamp":1785855456079,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to assess the effectiveness of simvastatin (SMV) in combination with alpha tricalcium phosphate (\u03b1TCP) as pulpotomy agents in cariously exposed permanent mandibular molars with symptomatic irreversible pulpitis. Sixty patients were randomly assigned equally to either the SMV\u2010\u03b1TCP or MTA group. The overall success of the treatments was evaluated after 12 months. Pain levels were recorded by patients preoperatively and postoperatively at intervals of 6, 12, 18\u2009h and days 1 through 7. No significant difference in success rates was found between the SMV\u2010\u03b1TCP (92.5%) and MTA (96.2%) groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Although a significant difference in pain intensity was noted between the groups on the first and second days (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), no significant differences in pain levels were observed at any other time points. The outcomes of this study suggest that SMV can be effectively utilised as a pulpotomy agent in carious permanent teeth.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT04374214.\n                  <\/jats:p>","DOI":"10.1111\/aej.70062","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:09:35Z","timestamp":1770448175000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Simvastatin on Success of Pulpotomy in Carious Permanent Molars With Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"52","author":[{"given":"Sudeepender","family":"Gehlot","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0693-2155","authenticated-orcid":false,"given":"Vinay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-9860","authenticated-orcid":false,"given":"Shweta","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigyasa","family":"Duhan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-8978","authenticated-orcid":false,"given":"Pankaj","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-6667","authenticated-orcid":false,"given":"Nishant","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.08.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747\u20104477.2002.tb00364.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/464280"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.09.009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/82219"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500608"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4248\/ijos.08011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2017.1403648"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349\u20107006.2007.00471.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.021"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.11.024"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106831\u201014\u201087"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.09.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31559"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.11223\/jarde.7.143"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.12.036"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010020\u201002326\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010005\u20102216"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053\u20104625\u201042.5.7"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010005\u20102720"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13294"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12196"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.05.008"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.21608\/ajdsm.2020.25745.1031"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisppd.jisppd_60_21"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCD.JCD_418_19"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.005"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(91)90312\u2010z"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.02.004"}],"container-title":["Australian Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aej.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:38:11Z","timestamp":1785854291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aej.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aej.70062"],"URL":"https:\/\/doi.org\/10.1111\/aej.70062","archive":["Portico"],"relation":{},"ISSN":["1329-1947","1747-4477"],"issn-type":[{"value":"1329-1947","type":"print"},{"value":"1747-4477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}