{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:57:36Z","timestamp":1785855456072,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This systematic review and meta\u2010analysis evaluated the association between apical periodontitis (AP) and non\u2010invasive markers of arterial stiffness, including carotid intima\u2010media thickness (c\u2010IMT), endothelial flow reserve (EFR), flow mediated dilatation (FMD), carotid plaques and aortic atherosclerotic burden (AAB) in systemically healthy individuals. PubMed\/MEDLINE, Cochrane, Scopus and EMBASE were searched. Quality assessment was done using the Newcastle\u2010Ottawa Scale. Six studies were selected, with two at low and four at moderate risk of bias. Five studies (two c\u2010IMT; three EFR) underwent meta\u2010analysis. Pooled analysis demonstrated that AP was significantly associated with increased c\u2010IMT (mean difference: 0.16\u2009mm; 95% CI: 0.02\u20130.30;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and reduced EFR (mean difference: \u22120.30; 95% CI: \u22120.43 to \u22120.16;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Heterogeneity was high for c\u2010IMT (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200984%), and absent for EFR (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%). Evidence quality was \u2018low\u2019 for c\u2010IMT and \u2018moderate\u2019 for EFR (GRADEpro). AP is associated with increased arterial stiffness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO: CRD420251047888\n                  <\/jats:p>","DOI":"10.1111\/aej.70084","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:25:34Z","timestamp":1776655534000},"page":"641-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Non\u2010Invasive Detection of Arterial Stiffness Related to Endothelial Dysfunction in Apical Periodontitis Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-6667","authenticated-orcid":false,"given":"Nishant","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences (PGIDS)  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-9860","authenticated-orcid":false,"given":"Shweta","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences (PGIDS)  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences (PGIDS)  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13467"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13364"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.07.007"},{"issue":"5","key":"e_1_2_12_6_1","first-page":"211","article-title":"Relationship Between Cardiovascular Disease and Dental Pathology. 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