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This umbrella review aimed to synthesize systematic reviews evaluating determinants of VPT outcomes in cariously exposed mature permanent teeth, and to appraise methodological quality and primary study overlap. Electronic searches across major databases and grey literature were conducted. Methodological quality was assessed using AMSTAR\u20102, and overlap quantified using the corrected covered area (CCA). Fourteen reviews were included, with moderate overlap and predominantly low to critically low confidence. Material\u2010related factors showed the most consistent association, with hydraulic calcium silicate\u2013based materials reporting higher success. Other factors showed inconsistent or non\u2010significant effects. Delayed restoration reduced success, and follow\u2010up duration influenced outcomes. Material selection appears the most consistent determinant, although overall evidence certainty remains limited.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    International Prospective Register of Systematic Reviews (PROSPERO) CRD420251275599\n                  <\/jats:p>","DOI":"10.1111\/aej.70115","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:45:15Z","timestamp":1785822315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Vital Pulp Therapy Success in Cariously Exposed Mature Permanent Teeth: An Umbrella Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6595-6244","authenticated-orcid":false,"given":"Rahul","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of 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