{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:18:58Z","timestamp":1774527538650,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T00:00:00Z","timestamp":1370563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Postpartum dysgalactia syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) in sows is an important disease after parturition with a relevant economic impact, affecting the health and welfare of both sows and piglets. The genetic background of this disease has been discussed and its heritability estimated, but further genetic analyses are lacking in detail. The aim of the current study was to detect loci affecting the susceptibility to <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> through a genome\u2010wide association approach. The study was designed as a family\u2010based association study with matched sampling of affected sows and healthy half\u2010 or full\u2010sib control sows on six farms. For the study, 597 sows (322 affected vs. 275 healthy control sows) were genotyped on 62\u00a0163 single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) using the Illumina Porcine<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>60 BeadChip. After quality control, 585 sows (314 affected vs. 271 healthy control sows) and 49\u00a0740 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s remained for further analysis. Statistics were performed mainly with the <jats:sc>r<\/jats:sc> package <jats:sc>genabel<\/jats:sc> and included a principal component analysis. A statistically significant genome\u2010wide associated <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> was identified on porcine chromosome (<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>) 17. Further promising results with moderate significance were detected on <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> 13 and on an unplaced scaffold with an older annotation on <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> 15. The <jats:styled-content style=\"fixed-case\"><jats:italic>PRICKLE2<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>NRP2<\/jats:italic><\/jats:styled-content> genes were identified as candidate genes near associated <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s. Several quantitative trait loci (<jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>) have been previously described in these genomic regions, including <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> for mammary gland condition, as teat number and non\u2010functional nipples <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>, as well as <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> for body temperature and gestation length.<\/jats:p>","DOI":"10.1111\/age.12047","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T10:38:42Z","timestamp":1370601522000},"page":"502-508","source":"Crossref","is-referenced-by-count":10,"title":["A genome\u2010wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines"],"prefix":"10.1111","volume":"44","author":[{"given":"Regine","family":"Preissler","sequence":"first","affiliation":[{"name":"Institute of Agricultural and Nutritional Sciences Martin\u2010Luther\u2010University Halle\u2010Wittenberg Theodor\u2010Lieser\u2010Stra\u00dfe 11 D\u201006120 Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Tetens","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Husbandry Christian\u2010Albrechts\u2010University Olshausenstra\u00dfe 40 D\u201024098 Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Reiners","sequence":"additional","affiliation":[{"name":"PIC Germany Ratsteich 31 D\u201024837 Schleswig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Looft","sequence":"additional","affiliation":[{"name":"PIC Germany Ratsteich 31 D\u201024837 Schleswig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Kemper","sequence":"additional","affiliation":[{"name":"Institute of Agricultural and Nutritional Sciences Martin\u2010Luther\u2010University Halle\u2010Wittenberg Theodor\u2010Lieser\u2010Stra\u00dfe 11 D\u201006120 Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm108"},{"key":"e_1_2_6_3_1","first-page":"526","article-title":"Bacteriological studies of the mastitis\u2010metritis\u2010agalactia syndrome in Austrian pig farms","volume":"45","author":"Awad Masalmeh M.","year":"1990","journal-title":"Tierarztliche Umschau"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.10.2.181"},{"key":"e_1_2_6_5_1","volume-title":"52nd Annual Meeting of the European Association for Animal Production, Budapest","author":"Berg P.","year":"2001"},{"key":"e_1_2_6_6_1","first-page":"557","article-title":"Reduction of the incidence of puerperal mastitis in the sow by protection of the mammary\u2010gland against fecal contamination","volume":"132","author":"Bertschinger H.U.","year":"1990","journal-title":"Schweizer Archiv f\u00fcr Tierheilkunde"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731108002097"},{"key":"e_1_2_6_8_1","first-page":"332","article-title":"Clinical examinations on gilts with puerperal septicaemia and toxaemia","volume":"26","author":"Bostedt H.","year":"1998","journal-title":"Tier\u00e4rztliche Praxis Ausgabe Grosstiere Nutztiere"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq468"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80371-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2003.68.69"},{"key":"e_1_2_6_12_1","first-page":"97","article-title":"Coliform mastitis in sows: a review","volume":"17","author":"Gerjets I.","year":"2009","journal-title":"Journal of Swine Health and Production"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4081\/vsd.2011.2479","article-title":"Application of decision\u2010tree technique to assess herd specific risk factors for coliform mastitis in sows","volume":"1","author":"Gerjets I.","year":"2011","journal-title":"Veterinary Science Development"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2011.04.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.05.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1989.tb00760.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2008.01756.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2003.00524.x"},{"key":"e_1_2_6_19_1","first-page":"990","article-title":"Untersuchungen zum Einfluss verschiedener Haltungsfaktoren auf die H\u00e4ufigkeit von Puerperalerkrankungen bei Sauen","volume":"83","author":"Hoy S.","year":"2002","journal-title":"Praktischer Tierarzt"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-005-0060-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-007-9086-5"},{"key":"e_1_2_6_22_1","first-page":"149","article-title":"Genetic variation for MMA treatment","volume":"81","author":"Krieter J.","year":"2009","journal-title":"Z\u00fcchtungskunde"},{"key":"e_1_2_6_23_1","first-page":"I\/26","article-title":"Effects of lactulose on the intestinal microflora of periparturient sows and their piglets","volume":"41","author":"Kr\u00fcger M.","year":"2002","journal-title":"European Journal of Nutrition"},{"key":"e_1_2_6_24_1","first-page":"833","volume-title":"Diseases of Swine","author":"Klopfenstein C.","year":"2006"},{"key":"e_1_2_6_25_1","first-page":"115","article-title":"Epidemiological and genetical studies in Norwegian pig herds. V. Estimates of heritability and phenotypic correlations of the most common diseases in Norwegian pigs","volume":"32","author":"Lingaas F.","year":"1991","journal-title":"Acta Veterinaria Scandinavica"},{"key":"e_1_2_6_26_1","unstructured":"LoepfeP.J.(1993)Experimentelle Mastitis bei der Sau. Korrelation der pathologisch\u2010anatomischen und histologischen Befunde mit den klinischen Befunden 4\u201030 Tage nach der Ansteckung mit E.\u00a0coli und Klebsiella pneumoniae. PhD\u2010Thesis Institut f\u00fcr Veterin\u00e4rbakteriologie Universit\u00e4t Z\u00fcrich Z\u00fcrich."},{"key":"e_1_2_6_27_1","first-page":"270","volume-title":"Diseases of Swine,","author":"Martineau G.\u2010P.","year":"2012"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_6_29_1","first-page":"90","article-title":"Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth","volume":"61","author":"Miyata S.","year":"2008","journal-title":"Neuroscience Research"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1335"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0388.2011.00969.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006524"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.01.011"},{"key":"e_1_2_6_35_1","unstructured":"RingarpN.(1960)Clinical and experimental investigations into a post\u2010parturient syndrome with agalactia in sows. PhD Thesis Department of Obstetrics and Gynaecology Royal Veterinary College Uppsala."},{"key":"e_1_2_6_36_1","first-page":"1844","article-title":"Role of certain bacteria in mastitis\u2010metritis\u2010agalactia of sows","volume":"155","author":"Ross R.F.","year":"1969","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_37_1","first-page":"661","article-title":"Relationships between parturition and puerperal diseases of swine","volume":"38","author":"Schulz J.","year":"1983","journal-title":"Monatshefte f\u00fcr Veterin\u00e4rmedizin"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.42.110807.091432"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-010-9269-3"},{"key":"e_1_2_6_40_1","volume-title":"52nd Annual Meeting of the European Association for Animal Production, Budapest","author":"Waldmann K.\u2010H.","year":"2001"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359901047"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00838.x"},{"key":"e_1_2_6_43_1","unstructured":"ZhuY.. (2007)Early inflammatory response in periparturient sows to experimentally induced E.\u00a0coli Mastitis. PhD Thesis Division of Reproduction Department of Clinical Sciences Faculty of Veterinary Medicine and Animal Science Swedish University of Agricultural Sciences Uppsala."}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12047","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:02:35Z","timestamp":1696471355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,7]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/age.12047"],"URL":"https:\/\/doi.org\/10.1111\/age.12047","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,7]]}}}