{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:54:10Z","timestamp":1761929650012},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>An improvement in the proportion of gilts entering the herd that farrow a litter would increase overall herd performance and profitability. A significant proportion (10\u201330%) of gilts that enter the herd never farrow a litter; reproductive reasons account for approximately a third of gilt removals, with anestrous and failure to conceive the most common reasons for culling. Tools to select gilts for reproductive longevity through genomics or alternative phenotypes would be of great benefit to the producer. Ninety\u2010one gilts that failed to display behavioral estrus by 240\u00a0days (cases) and 127 pubertal littermates (controls) were genotyped with the Illumina Porcine <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>60 Beadchip. One hundred and seventy\u2010four <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s with the most significant associations were genotyped in an additional 86 cases and 103 controls. Twelve of these associations were significant in the final analysis. The most significant (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>1.5\u00a0\u00d7\u00a010<jats:sup>\u221214<\/jats:sup>) region associated with failure to attain puberty was on chromosome 4 surrounding the <jats:italic><jats:styled-content style=\"fixed-case\">NHLH<\/jats:styled-content>2<\/jats:italic> gene. Delayed pubertal development and age at first estrus have been associated with <jats:italic><jats:styled-content style=\"fixed-case\">NHLH<\/jats:styled-content>2<\/jats:italic> in mice. Because attainment of puberty is a complex trait, identifying genes that affect pubertal age would greatly contribute to our knowledge of reproductive development as well as overall fertility.<\/jats:p>","DOI":"10.1111\/age.12087","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T07:32:43Z","timestamp":1377502363000},"page":"130-132","source":"Crossref","is-referenced-by-count":21,"title":["Genome\u2010wide association with delayed puberty in swine"],"prefix":"10.1111","volume":"45","author":[{"given":"D.","family":"Nonneman","sequence":"first","affiliation":[{"name":"USDA\u2010ARS U.S. Meat Animal Research Center Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lents","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS U.S. Meat Animal Research Center Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rohrer","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS U.S. Meat Animal Research Center Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rempel","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS U.S. Meat Animal Research Center Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vallet","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS U.S. Meat Animal Research Center Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2011.00032"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0337"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2006.07.002"},{"key":"e_1_2_3_5_1","volume-title":"Guide for the Care and Use of Agricultural Animals in Research and Teaching","author":"FASS","year":"2010"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.051"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.071"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2004.03.006"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2009.01903.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.065987"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2010-3111"},{"key":"e_1_2_3_12_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2527\/2004.82141x","article-title":"The National Pork Producers Council Maternal Line National Genetic Evaluation Program: a comparison of six maternal genetic lines for female productivity measures over four parities","volume":"82","author":"Moeller S.J.","year":"2004","journal-title":"Journal of Animal Science"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2008-1756"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0040"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.05.004"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.03.011"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0600"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12087","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:23:09Z","timestamp":1696339389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,26]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/age.12087"],"URL":"https:\/\/doi.org\/10.1111\/age.12087","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,26]]}}}