{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:49:17Z","timestamp":1791272957785,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> markers associated with quantitative trait loci (<jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>) affecting host tolerance to gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) parasite infection are ideal targets for marker\u2010assisted selection. However, few studies in cattle have attempted to identify this type of <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> due to the difficulty of generating accurate phenotypic data from a resource population with adequate statistical power for detection. For this effort, we amassed fecal egg count (<jats:styled-content style=\"fixed-case\">FEC<\/jats:styled-content>) measures from annual natural field challenges with <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> nematodes that spanned 12 different contemporary groups of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ngus calves (1992\u20132000) derived from a closed breeding population. <jats:styled-content style=\"fixed-case\">FEC<\/jats:styled-content> and blood pepsinogen measures were taken weekly over a 26\u2010week period post\u2010weaning, and the <jats:styled-content style=\"fixed-case\">FEC<\/jats:styled-content> data were <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ox\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox transformed to normalize the distribution of phenotypes. These 305 test animals and more than 100 founding animals from the extended pedigree were genotyped across 190 microsatellites markers. The genome\u2010wide analyses identified a suggestive genome\u2010wide <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> on bovine chromosome (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hr) 8 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.002) and nominal <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hr 4, 12 and 17 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). These findings were unique for cattle, and some corresponded to previously identified <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> locations for parasite\u2010related traits in sheep to provide genome locations for further fine mapping of parasite resistance\/susceptibility in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ngus cattle.<\/jats:p>","DOI":"10.1111\/age.12101","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T05:52:43Z","timestamp":1386222763000},"page":"117-121","source":"Crossref","is-referenced-by-count":12,"title":["Identification of quantitative trait loci affecting gastrointestinal parasite resistance in an experimental <scp>A<\/scp>ngus population"],"prefix":"10.1111","volume":"45","author":[{"given":"Eui\u2010Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Bovine Functional Genomics Laboratory USDA ARS Beltsville MD 20705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tad S.","family":"Sonstegard","sequence":"additional","affiliation":[{"name":"Bovine Functional Genomics Laboratory USDA ARS Beltsville MD 20705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicius G. B.","family":"Silva","sequence":"additional","affiliation":[{"name":"Bovine Functional Genomics Laboratory USDA ARS Beltsville MD 20705 USA"},{"name":"Embrapa Dairy Cattle Center Juiz de Fora MG 36038\u2010330 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis C.","family":"Gasbarre","sequence":"additional","affiliation":[{"name":"Bovine Functional Genomics Laboratory USDA ARS Beltsville MD 20705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis P.","family":"Van Tassell","sequence":"additional","affiliation":[{"name":"Bovine Functional Genomics Laboratory USDA ARS Beltsville MD 20705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90045-O"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-96"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800788"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(90)90009-Z"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00423-X"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.08.018"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9686-41-46"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2008.01832.x"},{"key":"e_1_2_3_10_1","first-page":"41","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"2","author":"Lander E.S.","year":"1995","journal-title":"Nature Genetics"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2008.01836.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9686-33-6-605"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.02.043"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2005.01337.x"},{"key":"e_1_2_3_15_1","first-page":"112","article-title":"Box\u2010Cox transformation and random regression models for fecal egg count data","volume":"2","author":"da Silva M.V.","year":"2011","journal-title":"Frontiers in genetics"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00563-5"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1988.tb00797.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001557"},{"key":"e_1_2_3_19_1","first-page":"845","article-title":"Drug resistance in veterinary helminthes","volume":"26","author":"Wolstenholme A.J.","year":"2004","journal-title":"Trends in Parasitology"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:23:15Z","timestamp":1696339395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/age.12101"],"URL":"https:\/\/doi.org\/10.1111\/age.12101","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,5]]}}}