{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:10Z","timestamp":1791288670453,"version":"4.3.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ovine lentivirus (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) is a macrophage\u2010tropic lentivirus found in many countries that causes interstitial pneumonia, mastitis, arthritis and cachexia in sheep. There is no preventive vaccine and no cure, but breed differences suggest marker\u2010assisted selective breeding might improve odds of infection and control of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> post\u2010infection. Although variants in <jats:italic><jats:styled-content style=\"fixed-case\">TMEM<\/jats:styled-content>154<\/jats:italic> have consistent association with odds of infection, no variant in any gene has been associated with host control of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> post\u2010infection in multiple animal sets. Proviral concentration is a live\u2010animal diagnostic measure of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> control post\u2010infection related to severity of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010induced lesions. A recent genome\u2010wide association study identified a region including four zinc finger genes associated with proviral concentration in one <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ambouillet flock. To refine this region, we tested additional variants and identified a small insertion\/deletion variant near <jats:italic><jats:styled-content style=\"fixed-case\">ZNF<\/jats:styled-content>389<\/jats:italic> that showed consistent association with proviral concentration in three animal sets (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). These animal sets contained <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ambouillet, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>olypay and crossbred sheep from multiple locations and management conditions. Strikingly, one flock had exceptionally high prevalence (&gt;87%, including yearlings) and mean proviral concentration (&gt;950\u00a0copies\/\u03bcg), possibly due to needle sharing. The best estimate of proviral concentration by genotype, obtained from all 1310 <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010positive animals tested, showed insertion homozygotes had less than half the proviral concentration of other genotypes (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Future work will test additional breeds, management conditions and viral subtypes, and identify functional properties of the haplotype this deletion variant tracks. To our knowledge, this is the first genetic variant consistently associated with host control of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> post\u2010infection in multiple sheep flocks.<\/jats:p>","DOI":"10.1111\/age.12107","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T09:06:38Z","timestamp":1386234398000},"page":"297-300","source":"Crossref","is-referenced-by-count":23,"title":["Deletion variant near <i><scp>ZNF<\/scp>389<\/i> is associated with control of ovine lentivirus in multiple sheep flocks"],"prefix":"10.1111","volume":"45","author":[{"given":"S. N.","family":"White","sequence":"first","affiliation":[{"name":"Animal Disease Research Unit Agricultural Research Service U.S. Department of Agriculture Pullman WA 99164 USA"},{"name":"Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Mousel","sequence":"additional","affiliation":[{"name":"U.S. Sheep Experiment Station Dubois ID 83423 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. O.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Animal Disease Research Unit Agricultural Research Service U.S. Department of Agriculture Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Herrmann\u2010Hoesing","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. P.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Animal Disease Research Unit Agricultural Research Service U.S. Department of Agriculture Pullman WA 99164 USA"},{"name":"Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2010.02100.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(03)00086-2"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/461168a"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2011.12.003"},{"key":"e_1_2_4_6_1","first-page":"E313","article-title":"Commercial application of marker\u2010 and gene\u2010assisted selection in livestock: strategies and lessons","volume":"82","author":"Dekkers J.C.","year":"2004","journal-title":"Journal of Animal Science"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002467"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055490"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00095-07"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-008-0328-9"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00459-08"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1613-8_6"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(83)90064-0"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(84)90065-8"},{"key":"e_1_2_4_15_1","first-page":"1","volume-title":"Ovine Progressive Pneumonia: Awareness, Management, and Seroprevalence","author":"InfoSheet","year":"2003"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00440-12"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(96)01101-4"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001258"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016210790416415"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2004014"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.05.008"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.121749.111"},{"key":"e_1_2_4_23_1","first-page":"233","article-title":"Maedi\u2010visna virus and its relationship to human immunodeficiency virus","volume":"7","author":"Thormar H.","year":"2005","journal-title":"AIDS Reviews"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047829"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101676108"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/age.12107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:15:17Z","timestamp":1696511717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,5]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/age.12107"],"URL":"https:\/\/doi.org\/10.1111\/age.12107","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,5]]}}}