{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T06:25:35Z","timestamp":1745043935519,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:00:00Z","timestamp":1404432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["295458"],"award-info":[{"award-number":["295458"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The protein\u2010coding region of <jats:italic>melanocortin 1 receptor<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic>) was sequenced to identify potential variation affecting coat color in reindeer (<jats:italic>Rangifer tarandus<\/jats:italic>). A T\u2192C sequence variation at nucleotide position 218 (c.218T&gt;C) causing an amino acid (aa) change from methionine to threonine at aa position 73 (p.Met73Thr) was identified. In addition, a T\u2192G sequence variation was found at nucleotide position 839 (c.839T&gt;G), causing phenylalanine to be exchanged by cysteine at aa position 280 (p.Phe280Cys). The two sequence variants (c.218C and c.839G) were found to be closely associated with a darker belly coat compared with animals not having any of these two variants. The aa acid change p.Met73Thr affects the same position as p.Met73Lys previously reported to give constitutive activation of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R in black sheep (<jats:italic>Ovis aries<\/jats:italic>), whereas p.Phe280Cys is identical to one of two variants previously reported to be associated with dark coat color in Arctic fox (<jats:italic>Alopex lagopus<\/jats:italic>), supporting that the two variants found in reindeer are functional. The complete absence of Thr73 and Cys280 among the 51 wild reindeer analyzed provides some evidence that these variants are more common in the domestic herds.<\/jats:p>","DOI":"10.1111\/age.12187","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T13:03:07Z","timestamp":1404478987000},"page":"750-753","source":"Crossref","is-referenced-by-count":11,"title":["Two missense mutations in <i>melanocortin 1 receptor<\/i> (<i><scp>MC<\/scp>1R<\/i>) are strongly associated with dark ventral coat color in reindeer (<i>Rangifer tarandus<\/i>)"],"prefix":"10.1111","volume":"45","author":[{"given":"D. I.","family":"V\u00e5ge","sequence":"first","affiliation":[{"name":"Centre for Integrative Genetics (CIGENE) Department of Animal and Aquacultural Sciences (IHA) Norwegian University of Life Sciences (NMBU) \u00c5s N\u20101432 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Reindeer Research Station Finnish Game and Fisheries Research Institute Kaamanen 99910 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Social Science University of Aberdeen Aberdeen AB24 4QY Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"R\u00f8ed","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine Norwegian University of Life Sciences (NMBU) Oslo N\u20100033 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/668011"},{"volume-title":"Forest Reindeer Herding A.D. 1\u20131800: An Archaeological and Palaeoecological Study in Northern Sweden","year":"1991","author":"Aronsson K.\u00c5.","key":"e_1_2_3_3_1"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1346"},{"key":"e_1_2_3_5_1","first-page":"29","volume-title":"Exploitation des Animaux Sauvage \u00e1 Travers le Temps","author":"David F.","year":"1993"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000341"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048526"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2052.2003.00991.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00352371"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1999.00039.x"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.09.013"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2013.03.015"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900264"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2013.03.014"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90572-8"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1153"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-311"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900939"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.040"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5667"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12187","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:55:17Z","timestamp":1696506917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/age.12187"],"URL":"https:\/\/doi.org\/10.1111\/age.12187","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"type":"print","value":"0268-9146"},{"type":"electronic","value":"1365-2052"}],"subject":[],"published":{"date-parts":[[2014,7,4]]}}}