{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:12:19Z","timestamp":1762866739388},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T00:00:00Z","timestamp":1445126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1508085QC52","1408085QC55"],"award-info":[{"award-number":["1508085QC52","1408085QC55"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171200"],"award-info":[{"award-number":["31171200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Some polymorphisms of the human <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> gene are causally and significantly associated with serum lipids levels; however, the information regarding this gene in pigs is sparse. To evaluate the effects of <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> on blood lipid traits and fat deposition in pig, porcine <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> tissue expression patterns were observed by quantitative real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>) first. High expression was detected in liver, spleen, gluteus medius (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) muscle and backfat. A <jats:italic>de novo<\/jats:italic> polymorphism (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>333037:g.795C&gt;T) in the intron 1 region of porcine <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> was identified. This polymorphism was further genotyped by direct sequencing of the <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> products of 390 Wannan Black pigs, a Chinese native breed population. Association analyses at 45 and 300\u00a0days of age revealed highly significant associations between <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> genotypes and serum lipid traits. Furthermore, this polymorphism was proved to be associated with differences in liver <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels: pigs at 300\u00a0days of age with the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype had higher levels than did those with other genotypes (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.021). Additionally, analysis at 300\u00a0days of age showed that <jats:styled-content style=\"fixed-case\">GM <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression correlated positively with serum lipids levels as well as with carcass backfat thickness and intramuscular fat content in <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>. These results indicate that <jats:italic><jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content><\/jats:italic> is involved in serum, adipose and muscle lipid metabolism in pigs. The mechanisms underlying such relationships and their functional implications are worthy of further research.<\/jats:p>","DOI":"10.1111\/age.12370","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T04:52:50Z","timestamp":1445230370000},"page":"702-706","source":"Crossref","is-referenced-by-count":5,"title":["Functional and association studies of the <i>cholesteryl ester transfer protein<\/i> (<i><scp>CETP<\/scp><\/i>) gene in a Wannan Black pig model"],"prefix":"10.1111","volume":"46","author":[{"given":"Y. Y.","family":"Ding","sequence":"first","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Q.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ding","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. L.","family":"He","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. D.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Huang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Laboratory for Local Livestock and Poultry Genetic Resource Conservation and Bio\u2010Breeding Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei Anhui 230036 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731109991145"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R027011"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-848"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2015.1005215"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.90249.2008"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12041"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.12.032"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-758"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5517"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2012.05.015"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.12.002"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.6.1759"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031930"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12035"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.02.008"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731107000018"},{"key":"e_1_2_3_18_1","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.2527\/2002.8051390x","article-title":"Rapid communication: genetic linkage and physical mapping of the porcine cholesteryl ester transfer protein (CETP) gene","volume":"80","author":"Shi X.W.","year":"2002","journal-title":"Journal of Animal Science"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-12-62"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.073"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13353-012-0131-z"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-176"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02186.x"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12155"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12370","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:39:54Z","timestamp":1696513194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,18]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/age.12370"],"URL":"https:\/\/doi.org\/10.1111\/age.12370","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,18]]}}}