{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:07:53Z","timestamp":1782860873356,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","award":["RFO2014"],"award-info":[{"award-number":["RFO2014"]}],"id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A feral donkey population (<jats:italic>Equus asinus<\/jats:italic>), living in the Asinara National Park (an island north\u2010west of Sardinia, Italy), includes a unique white albino donkey subpopulation or colour morph that is a major attraction of this park. Disrupting mutations in the <jats:italic>tyrosinase<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">TYR<\/jats:styled-content><\/jats:italic>) gene are known to cause recessive albinisms in humans (oculocutaneous albinism Type 1; <jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content>1) and other species. In this study, we analysed the donkey <jats:italic><jats:styled-content style=\"fixed-case\">TYR<\/jats:styled-content><\/jats:italic> gene as a strong candidate to identify the causative mutation of the albinism of these donkeys. The <jats:italic><jats:styled-content style=\"fixed-case\">TYR<\/jats:styled-content><\/jats:italic> gene was sequenced from 13 donkeys (seven Asinara white albino and six coloured animals). Seven single nucleotide polymorphisms were identified. A missense mutation (c.604C&gt;G; p.His202Asp) in a highly conserved amino acid position (even across kingdoms), which disrupts the first copper\u2010binding site (CuA) of functional protein, was identified in the homozygous condition (G\/G or D\/D) in all Asinara white albino donkeys and in the albino son of a trio (the grey parents had genotype C\/G or H\/D), supporting the recessive mode of inheritance of this mutation. Genotyping 82 donkeys confirmed that Asinara albino donkeys had genotype G\/G whereas all other coloured donkeys had genotype C\/C or C\/G. Across\u2010population association between the c.604C&gt;G genotypes and the albino coat colour was highly significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a06.17E\u221218). The identification of the causative mutation of the albinism in the Asinara white donkeys might open new perspectives to study the dynamics of this putative deleterious allele in a feral population and to manage this interesting animal genetic resource.<\/jats:p>","DOI":"10.1111\/age.12386","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T09:15:59Z","timestamp":1447924559000},"page":"120-124","source":"Crossref","is-referenced-by-count":39,"title":["The albinism of the feral Asinara white donkeys (<i>Equus asinus<\/i>) is determined by a missense mutation in a highly conserved position of the tyrosinase (<i><scp>TYR<\/scp><\/i>) gene deduced protein"],"prefix":"10.1111","volume":"47","author":[{"given":"V. J.","family":"Utzeri","sequence":"first","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ribani","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schiavo","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dall'Olio","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fontanesi","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences Division of Animal Sciences University of Bologna Viale Fanin 46 40127 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010120"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2008.01788.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-004-4002-8"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131925"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00227.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2007.01619.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2005.07.012"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2012.02356.x"},{"key":"e_1_2_4_10_1","first-page":"25","article-title":"Genetic relationships among donkey populations living in Sardinia: an analysis using molecular markers","volume":"12","author":"Cosseddu G.M.","year":"2001","journal-title":"Ippologia"},{"issue":"15","key":"e_1_2_4_11_1","first-page":"5","article-title":"Comparative protein structure modeling with modeller","volume":"15","author":"Eswar N.","year":"2006","journal-title":"Current Protocols in Bioinformatics"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2014.881369"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.02012.x"},{"key":"e_1_2_4_14_1","unstructured":"Gazzetta Ufficiale della Repubblica Italiana(1997)Disposizioni per lo sviluppo e la qualificazione degli interventi e dell'occupazione in campo ambientale. 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