{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:04:09Z","timestamp":1778868249819,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The bovine rumen papillae are in contact with a wide array of microorganisms and the metabolites they produce, which may activate an inflammatory and\/or immune response. Cytokines, chemokines and their receptor genes were tested for differential expression in the rumen and jejunum of beef steers with greater and lesser average daily body weight gain (<jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content>) near the average daily dry matter intake (<jats:styled-content style=\"fixed-case\">DMI<\/jats:styled-content>) for the population. Angus\u2010sired steers (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) were used to represent the greater (<jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content>\u00a0=\u00a02.2\u00a0\u00b1\u00a00.07\u00a0kg\/day; <jats:styled-content style=\"fixed-case\">DMI<\/jats:styled-content>\u00a0=\u00a010.1\u00a0\u00b1 0.05\u00a0kg\/day) and lesser (<jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content>\u00a0=\u00a01.7\u00a0\u00b1\u00a00.05\u00a0kg\/day; <jats:styled-content style=\"fixed-case\">DMI<\/jats:styled-content>\u00a0=\u00a010.1\u00a0\u00b1\u00a00.05\u00a0kg\/day) <jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content> groups with eight steers each. Rumen epithelium and jejunum mucosal samples were collected at slaughter, and gene expression was evaluated using a commercially available <jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> array containing 84 genes representing chemokines, cytokines and their receptors. None of the genes on the array were differentially expressed in the jejunum of the steers with greater vs. lesser <jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content>. However, in the rumen, two chemokine genes (<jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>11<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>5<\/jats:italic>) and one receptor gene (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content><\/jats:italic>) were detected as differentially expressed (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The genes <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1A, <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>12<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TNFSF<\/jats:styled-content>13<\/jats:italic> also displayed trends for differential expression (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.10). All of the genes identified were lower in transcript abundance in the greater <jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content> animals. Thus, greater <jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content> steers have a lesser inflammatory response in the rumen papillae, which may lead to a more efficient use of nutrients.<\/jats:p>","DOI":"10.1111\/age.12546","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:38:19Z","timestamp":1487695099000},"page":"447-449","source":"Crossref","is-referenced-by-count":14,"title":["Relationships between inflammation\u2010 and immunity\u2010related transcript abundance in the rumen and jejunum of beef steers with divergent average daily gain"],"prefix":"10.1111","volume":"48","author":[{"given":"J. G.","family":"Reynolds","sequence":"first","affiliation":[{"name":"USDA, ARS, U.S. Meat Animal Research Center  Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Foote","sequence":"additional","affiliation":[{"name":"USDA, ARS, U.S. Meat Animal Research Center  Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Freetly","sequence":"additional","affiliation":[{"name":"USDA, ARS, U.S. Meat Animal Research Center  Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. T.","family":"Oliver","sequence":"additional","affiliation":[{"name":"USDA, ARS, U.S. Meat Animal Research Center  Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Lindholm\u2010Perry","sequence":"additional","affiliation":[{"name":"USDA, ARS, U.S. Meat Animal Research Center  Clay Center NE 68933\u20100166 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.03.016"},{"key":"e_1_2_3_3_1","doi-asserted-by":"crossref","first-page":"25277","DOI":"10.1016\/S0021-9258(18)47243-2","article-title":"Cloning and characterization of the human neutrophil\u2010activating peptide (ENA\u201078) gene","volume":"269","author":"Chang M.S.","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1409-1422.2004"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-8291"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4846"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.03.034"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12440"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813476055"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118456"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-016-0100-1"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25907"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:39:42Z","timestamp":1696491582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/age.12546"],"URL":"https:\/\/doi.org\/10.1111\/age.12546","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}