{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:40:28Z","timestamp":1790318428004,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31272413"],"award-info":[{"award-number":["31272413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1303284"],"award-info":[{"award-number":["U1303284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["250633"],"award-info":[{"award-number":["250633"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fat\u2010tailed sheep (<jats:italic>Ovis aries<\/jats:italic>) can survive in harsh environments and satisfy human's intake of dietary fat. However, the animals require more feed, which increases the cost of farming. Thus, most farmers currently prefer thin\u2010tailed, short\u2010tailed or docked sheep. To date, the molecular mechanism of the formation of fat tails in sheep has not been completely elucidated. Here, we conducted a genome\u2010wide association study using phenotypes and genotypes (the Ovine Infinium <jats:styled-content style=\"fixed-case\">HD SNP<\/jats:styled-content> BeadChip genotype data) of two breeds of contrasting tail types (78 Small\u2010tailed and 78 Large\u2010tailed Han sheep breeds) to identify functional genes and variants associated with fat deposition. We identified four significantly (rs416433540, rs409848439, rs408118325 and rs402128848) and three approximately associated autosomal <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs401248376, rs402445895 and rs416201901). Gene annotation indicated that the surrounding genes (<jats:italic><jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">STEAP<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CTBP<\/jats:styled-content>1<\/jats:italic> and <jats:italic>RIP140<\/jats:italic>, also known as <jats:italic>NRIP1<\/jats:italic>) function in lipid storage or fat cell regulation. Furthermore, through an X\u2010chromosome\u2010wide association analysis, we detected significantly associated <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">OARX<\/jats:styled-content>: 88\u201389\u00a0Mb region, which could be a strong candidate genomic region for fat deposition in tails of sheep. Our results represent a new genomic resource for sheep genetics and breeding. In addition, the findings provide novel insights into genetic mechanisms of fat deposition in the tail of sheep and other mammals.<\/jats:p>","DOI":"10.1111\/age.12572","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T03:32:37Z","timestamp":1499225557000},"page":"560-569","source":"Crossref","is-referenced-by-count":64,"title":["Genome\u2010wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (<i>Ovis aries<\/i>)"],"prefix":"10.1111","volume":"48","author":[{"given":"S.\u2010S.","family":"Xu","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"University of Chinese Academy of Sciences (UCAS) Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ren","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"Annoroad Gene Technology Co. Ltd Beijing 100176 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.\u2010L.","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"Department of Life Sciences Shangqiu Normal University Shangqiu 476000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010L.","family":"Xie","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"University of Chinese Academy of Sciences (UCAS) Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"University of Chinese Academy of Sciences (UCAS) Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"},{"name":"School of Life Sciences University of Science and Technology of China Hefei 230027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.\u2010Q.","family":"Shen","sequence":"additional","affiliation":[{"name":"Shandong Binzhou Academy of Animal Science and Veterinary Medicine Binzhou 256600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010L.","family":"Ren","sequence":"additional","affiliation":[{"name":"Shandong Binzhou Academy of Animal Science and Veterinary Medicine Binzhou 256600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China"},{"name":"State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China"},{"name":"State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kantanen","sequence":"additional","affiliation":[{"name":"Green Technology Natural Resources Institute Finland (Luke) Jokioinen 31600 Finland"},{"name":"Department of Environmental and Biological Sciences University of Eastern Finland Kuopio 70211 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010H.","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences (CAS) Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-011-9855-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0464-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2006.03.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802674106"},{"key":"e_1_2_8_7_1","volume-title":"Livestock Breeds of China\u2010Animal Production and Health Paper: FAO Animal Production & Health Paper","author":"Cheng P.","year":"1984"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00443-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.21.9383-9391.2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3198"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1705"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02553.x"},{"key":"e_1_2_8_13_1","first-page":"93","article-title":"Meat from culled old ewes of two fat\u2010tailed Iranian breeds. II. Meat, subcutaneous fat and bone in wholesale cuts","volume":"2","author":"Farid A.","year":"1983","journal-title":"Iran Agricultural Research"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1681308"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.10.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02110"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.03.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129359"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1666108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2005.01.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.025"},{"key":"e_1_2_8_22_1","first-page":"13","article-title":"DNA extraction and quantitation of forensic samples using the phenol\u2010chloroform method and real\u2010time PCR","volume":"297","author":"K\u00f6chl S.","year":"2005","journal-title":"Methods in Molecular Biology"},{"key":"e_1_2_8_23_1","unstructured":"LeeD.(2014)The Role of CREB in the Liver and Adipose Tissue(Ph.D. dissertation). University of Pennsylvania."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401013101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1671-2927(06)60137-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu264"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msv139"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10592-005-8670-z"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094911"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085068"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2015-9389"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-13-10"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2011.611601"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24371"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.001"},{"key":"e_1_2_8_37_1","first-page":"645","article-title":"Selection in fat\u2010tailed sheep based on two traits of fat\u2010tail and body weight versus single\u2010trait total body weight","volume":"4","author":"Nejati\u2010Javaremi A.","year":"2007","journal-title":"International Journal of Agriculture & Biology"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-003681"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.03.008"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26040"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217149109"},{"key":"e_1_2_8_43_1","volume-title":"Sheep and Man","author":"Ryder M.L.","year":"1983"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2008.03.007"},{"key":"e_1_2_8_45_1","unstructured":"SPSS. (2013)IBM SPSS Statistics 22. Algorithms.IBM SPSS Inc. Chicago IL."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004127"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01899-08"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15048705"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.18.8311-8322.2005"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.39"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw129"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12477"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00793.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1005.2013.01384"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2310"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2007.40.4.525"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160920360"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27822"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:37:16Z","timestamp":1695040636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,4]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/age.12572"],"URL":"https:\/\/doi.org\/10.1111\/age.12572","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,4]]}}}