{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:13:27Z","timestamp":1780406007233,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Non\u2010syndromic congenital cleft lip and jaw (<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>) is a condition reported in Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle. The objective of the present study was to perform a genome\u2010wide association study (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>) for 10<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>\u2010affected and 50 unaffected Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle using the bovine Illumina high density bead chip to identify loci for this condition. Phenotypic classification of<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>was based on a detailed recording of orofacial structures using computed tomography. A breeding experiment among<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>\u2010affected Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle and<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>\u2010affected Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle with unaffected Holsteins confirmed recessive inheritance and different loci for bilateral or left\u2010sided versus right\u2010sided<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>. The<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>for the five cases with right\u2010sided<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>gave a genome\u2010wide signal on bovine chromosome (<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>) 29 at 16\u00a0Mb. For the four left\u2010sided and one bilateral<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>case, a genome\u2010wide significant association was identified on<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>4 at 32\u00a0Mb. Two different loci are very likely to be involved in<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>in Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle because experimental matings among affected cows and bulls with different types of<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>did not result in<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>\u2010affected progeny, and in addition, two different loci were also found through<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>and mapped on two different bovine chromosomes. Validation in 346 Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle for the highly associated<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s on<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>4 and 29 gave ratios of 33\/346 (0.095,<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>4) and 6\/346 (0.017,<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>29) homozygous mutant genotypes. Further studies should elucidate the responsible mutations underlying the different types of<jats:styled-content style=\"fixed-case\">CLJ<\/jats:styled-content>in Vorderwald\u00a0\u00d7\u00a0Montb\u00e9liarde cattle.<\/jats:p>","DOI":"10.1111\/age.12584","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:08:43Z","timestamp":1500872923000},"page":"523-530","source":"Crossref","is-referenced-by-count":3,"title":["Breeding experiments and genome\u2010wide association analysis elucidate two genetically different forms of non\u2010syndromic congenital cleft lip and jaw in Vorderwald \u00d7 Montb\u00e9liarde cattle"],"prefix":"10.1111","volume":"48","author":[{"given":"S.","family":"Reinartz","sequence":"first","affiliation":[{"name":"Institute for Animal Breeding and Genetics University of Veterinary Medicine Hannover, Foundation B\u00fcnteweg 17p 30559 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Distl","sequence":"additional","affiliation":[{"name":"Institute for Animal Breeding and Genetics University of Veterinary Medicine Hannover, Foundation B\u00fcnteweg 17p 30559 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5194\/aab-47-141-2004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm308"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_8_6_1","volume-title":"Constitutional Disorders and Hereditary Diseases in Domestic Animals","author":"H\u00e1mori D.","year":"1983"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12099"},{"key":"e_1_2_8_8_1","first-page":"180","article-title":"Note sur deux cas de bec de li\u00e8vre constat\u00e9s parmi des veaux Shorthorn","volume":"26","author":"Hidiroglou M.","year":"1962","journal-title":"Canadian Journal of Comparative Medicine and Veterinary Science"},{"key":"e_1_2_8_9_1","first-page":"107","article-title":"Clinical, pathological and other visible traits loci except coat colour (category 2)","volume":"101","author":"Huston K.","year":"2000","journal-title":"EAAP Publication"},{"key":"e_1_2_8_10_1","first-page":"167","article-title":"Hereditarily conditioned anomalies of the facial part of the animal head","volume":"41","author":"Labik K.","year":"1972","journal-title":"Acta Veterinaria"},{"key":"e_1_2_8_11_1","first-page":"2862","article-title":"A multi\u2010ethnic genome\u2010wide association study identifies novel loci for non\u2010syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13","volume":"25","author":"Leslie E.J.","year":"2016","journal-title":"Human Molecular Genetics"},{"key":"e_1_2_8_12_1","first-page":"297","article-title":"Lippenkieferspalte beim kalb: anmerkungen zu dem artikel \u201cCornea\u2010dermoide und doppelmi\u00dfbildung der nasenl\u00f6cher bei einem rind\u201d von C. 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