{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:33:56Z","timestamp":1759160036203,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Male piglets are routinely castrated to eliminate boar taint. However, this treatment is undesirable, and alternative approaches, including genetic strategies to reduce boar taint, are demanded. Androstenone is one of the causative agents of boar taint, and a <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> region affecting this pheromone has previously been reported on <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>5: 22.6\u201324.8\u00a0Mb in Duroc. The <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> region is one of the few reported for androstenone that does not simultaneously affect levels of other sex steroids. The main objective of this study was to fine map this <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>. Whole genome sequence data from 23 Norwegian Duroc boars were analyzed to detect new polymorphisms within the <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> region. A subset of 161 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s was genotyped in 834 Duroc sires and analyzed for association with androstenone in adipose tissue and testosterone, estrone sulphate and 17<jats:italic>\u03b2<\/jats:italic>\u2010estradiol in blood plasma. Our results revealed 100 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s significantly associated with androstenone levels in fat (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) with 94 of the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s being in strong linkage disequilibrium in the region 23.03\u201324.27\u00a0Mb. This haplotype block contains at least four positional candidate genes (<jats:italic><jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>17B6<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">SDR<\/jats:styled-content>9C7<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">RDH<\/jats:styled-content>16<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6<\/jats:italic>) involved in androstenone biosynthesis. No significant associations were found between any of the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and levels of testosterone and estrogens, confirming previous findings. The amount of phenotypic variance explained by single <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s within the haplotype block was as high as 5.4%. As the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in this region significantly affect levels of androstenone without affecting levels of other sex steroids, they are especially interesting as genetic markers for selection against boar taint.<\/jats:p>","DOI":"10.1111\/age.12615","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T05:06:36Z","timestamp":1508130396000},"page":"653-659","source":"Crossref","is-referenced-by-count":6,"title":["Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-3387","authenticated-orcid":false,"given":"M.","family":"van Son","sequence":"first","affiliation":[{"name":"Topigs Norsvin Storhamargata 44 2317 Hamar Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences (IHA) Faculty of Life Sciences (BIOVIT) Centre for Integrative Genetics (CIGENE) Norwegian University of Life Sciences (NMBU) PO Box\u00a05003 1432 \u00c5s Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences (IHA) Faculty of Life Sciences (BIOVIT) Centre for Integrative Genetics (CIGENE) Norwegian University of Life Sciences (NMBU) PO Box\u00a05003 1432 \u00c5s Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences (IHA) Faculty of Life Sciences (BIOVIT) Centre for Integrative Genetics (CIGENE) Norwegian University of Life Sciences (NMBU) PO Box\u00a05003 1432 \u00c5s Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Grindflek","sequence":"additional","affiliation":[{"name":"Topigs Norsvin Storhamargata 44 2317 Hamar Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences (IHA) Faculty of Life Sciences (BIOVIT) Centre for Integrative Genetics (CIGENE) Norwegian University of Life Sciences (NMBU) PO Box\u00a05003 1432 \u00c5s Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/AN15279"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas1986.623632x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/521987"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(02)00015-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-7863"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20310"},{"key":"e_1_2_6_9_1","unstructured":"GarrisonE.&MarthG.(2012)Haplotype\u2010based variant detection from short\u2010read sequencing. 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