{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:13:28Z","timestamp":1782738808728,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Independent Research Council","award":["Grant Number DFF 1335-00127"],"award-info":[{"award-number":["Grant Number DFF 1335-00127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Taste receptors (<jats:styled-content style=\"fixed-case\">TASR<\/jats:styled-content>s) and appetite and reward (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) mechanisms influence eating behaviour, which in turn affects food intake and risk of obesity. In a previous study, we used next generation sequencing to identify potentially functional mutations in <jats:styled-content style=\"fixed-case\">TASR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> genes and found indications for genetic associations between identified variants and growth and fat deposition in a subgroup of animals (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>38) from the <jats:styled-content style=\"fixed-case\">UNIK<\/jats:styled-content> resource pig population. This population was created for studying obesity and obesity\u2010related diseases. In the present study we validated results from our previous study by investigating genetic associations between 24 selected single nucleotide variants in <jats:styled-content style=\"fixed-case\">TASR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> gene variants and 35 phenotypes describing obesity and metabolism in the entire <jats:styled-content style=\"fixed-case\">UNIK<\/jats:styled-content> population (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>564). Fifteen variants showed significant association with specific obesity\u2010related phenotypes after Bonferroni correction. Six of the 15 genes, namely <jats:italic><jats:styled-content style=\"fixed-case\">SIM<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content>2R4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content>2R9<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">MCHR<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">LEPR<\/jats:styled-content><\/jats:italic>, showed good correlation between known biological function and associated phenotype. We verified a genetic association between potentially functional variants in <jats:styled-content style=\"fixed-case\">TASR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> genes and growth\/obesity and conclude that the combination of identification of potentially functional variants by next generation sequencing followed by targeted genotyping and association studies is a powerful and cost\u2010effective approach for increasing the power of genetic association studies.<\/jats:p>","DOI":"10.1111\/age.12641","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T07:46:50Z","timestamp":1518594410000},"page":"110-118","source":"Crossref","is-referenced-by-count":10,"title":["A targeted genotyping approach enhances identification of variants in taste receptor and appetite\/reward genes of potential functional importance for obesity\u2010related porcine traits"],"prefix":"10.1111","volume":"49","author":[{"given":"S.","family":"Cirera","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Clop","sequence":"additional","affiliation":[{"name":"CSIC\u2010IRTA\u2010UAB\u2010UB Campus UAB Centre for Research in Agricultural Genomics (CRAG) 08193 Cerdanyola del Valles Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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