{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:46:53Z","timestamp":1790290013821,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001239","name":"Merck Institute for Science Education","doi-asserted-by":"publisher","award":["2017\u2010NAZ\u20100228 CUP: B78I17000260008"],"award-info":[{"award-number":["2017\u2010NAZ\u20100228 CUP: B78I17000260008"]}],"id":[{"id":"10.13039\/100001239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007706","name":"Ministero dello Sviluppo Economico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Microtia is a congenital deformity of the outer ear with phenotypes varying from a small auricle to total absence (anotia). The genetic basis is still poorly understood, and very few studies have been performed in sheep. Valle del Belice sheep is a breed showing microtia. The aim of this study was to identify the potential genomic regions involved in microtia in sheep. A total of 40 individuals, 20 with microtia and 20 normal, were genotyped with the Illumina Ovine<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>50 BeadChip. The comparison among the results from a genome\u2010wide association study, Fisher's exact test and <jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic><jats:sub>ST<\/jats:sub><\/jats:styled-content> analysis revealed a single strong association signal: rs419889303 on chromosome 1, located within intron 3 of the <jats:italic><jats:styled-content style=\"fixed-case\">CLRN<\/jats:styled-content>1<\/jats:italic> gene. Our study suggests for the first time that this novel candidate gene is responsible for microtia in sheep. Additional analysis based on the sequencing would help confirm our findings and allow for the proposal of a precise genetic basis for microtia in sheep.<\/jats:p>","DOI":"10.1111\/age.12719","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T14:56:09Z","timestamp":1535640969000},"page":"636-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genome\u2010wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-1981","authenticated-orcid":false,"given":"S.","family":"Mastrangelo","sequence":"first","affiliation":[{"name":"Dipartimento Scienze Agrarie, Alimentari e Forestali University of Palermo 90128 Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sottile","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Economiche, Aziendali e Statistiche University of Palermo 90128 Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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