{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:39:46Z","timestamp":1777480786333,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP\u201000370"],"award-info":[{"award-number":["PIP\u201000370"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The llama (<jats:italic>Lama glama<\/jats:italic>) is a fiber\u2010producing species that presents a wide range of coat colors, among which white is one of the most important for the textile industry. However, there is little information about the molecular mechanisms that control the white phenotype in this species. In domestic mammals, a white coat is usually produced by mutations in the <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content> proto\u2010oncogene receptor tyrosine kinase<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic>) and <jats:italic>microphthalmia\u2010associated transcription factor<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content><\/jats:italic>) genes. In this work we have sequenced and described the coding regions of <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010M,<\/jats:italic> the melanocyte\u2010specific isoform, and the two transcriptional variants <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010<\/jats:italic>M(\u2212) and <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010M<\/jats:italic>(+). Moreover, we studied the expression of these genes in the skin of white and colored llamas. Although no variants were revealed to be associated with white coat color, significant differences between phenotypes were observed in the expression levels of <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010M<\/jats:italic>. Interestingly, white llamas expressed less <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010M<\/jats:italic>(+) than did colored ones, which is consistent with a consequent reduction in the synthesis of melanin. Even though our results indicate that downregulation of <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010M<\/jats:italic> expression is involved in white phenotype production in llamas, the causative gene of white coat color remains unknown.<\/jats:p>","DOI":"10.1111\/age.12769","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T15:34:58Z","timestamp":1549553698000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterization and expression analysis of <i><scp>KIT<\/scp><\/i> and <i><scp>MITF<\/scp>\u2010M<\/i> genes in llamas and their relation to white coat color"],"prefix":"10.1111","volume":"50","author":[{"given":"M.","family":"Anello","sequence":"first","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto Multidisciplinario de Biolog\u00eda Celular (IMBICE) CONICET\u2010UNLP\u2010CIC Calle 526 e\/10 y 11 La\u00a0Plata 1900 Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Daverio","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto Multidisciplinario de Biolog\u00eda Celular (IMBICE) CONICET\u2010UNLP\u2010CIC Calle 526 e\/10 y 11 La\u00a0Plata 1900 Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Silbestro","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto Multidisciplinario de Biolog\u00eda Celular (IMBICE) CONICET\u2010UNLP\u2010CIC Calle 526 e\/10 y 11 La\u00a0Plata 1900 Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vidal\u2010Rioja","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto Multidisciplinario de Biolog\u00eda Celular (IMBICE) CONICET\u2010UNLP\u2010CIC Calle 526 e\/10 y 11 La\u00a0Plata 1900 Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Di Rocco","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto Multidisciplinario de Biolog\u00eda Celular (IMBICE) CONICET\u2010UNLP\u2010CIC Calle 526 e\/10 y 11 La\u00a0Plata 1900 Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.31.19560"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00249.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.03.060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.2011.00177.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2016.08.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv451"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12556"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12484"},{"key":"e_1_2_7_11_1","unstructured":"FrankE.N.(2001)Descripci\u00f3n y An\u00e1lisis de Segregaci\u00f3n de Fenotipos de Color y Tipos de Vell\u00f3n en Llamas Argentina. 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