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Cows with ketosis have lower milk yield and reproductive performance and greater risk of other periparturient diseases. As a metabolic disease, the pathogenesis of <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content> is multifactorial. To better understand the genetic background of <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content>, a genome\u2010wide association study was performed using the Illumina Bovine<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>50 BeadChip. Single\u2010step genomic <jats:styled-content style=\"fixed-case\">BLUP<\/jats:styled-content> methodology was used to incorporate genomic data into a threshold\u2010liability model. Results of the <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content> are reported as the proportion of variance explained by 20\u2010<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> windows. Six genomic regions on <jats:italic>Bos taurus<\/jats:italic> autosomes 10, 13, 14 and 25 showed association with <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content>. Most interestingly, several candidate genes, including previously reported genes (<jats:italic><jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">HNF<\/jats:styled-content>4A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">APOBR<\/jats:styled-content><\/jats:italic>) and newly identified genes (<jats:italic><jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>14<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>6<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>7A1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>3<\/jats:italic>), are involved in insulin metabolism or lipid metabolism, implicating the contribution of energy\u2010metabolism\u2010associated genes to the genetic basis of <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content>. Our results provide new information about the underlying biology and molecular mechanisms associated with <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content>. Future studies that combine genomic variation analysis and functional gene information may help elucidate the biology of <jats:styled-content style=\"fixed-case\">KET<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/age.12802","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T08:18:07Z","timestamp":1560154687000},"page":"376-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genome\u2010wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle"],"prefix":"10.1111","volume":"50","author":[{"given":"H.","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs National Engineering Laboratory of Animal Breeding College of Animal Science and Technology China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine College of Veterinary Medicine China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Hanif","sequence":"additional","affiliation":[{"name":"National Institute for Biotechnology and Genetic Engineering Pakistan Institute of Engineering and Applied Sciences Jhang Road Faisalabad 577 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs National Engineering Laboratory of Animal Breeding College of Animal Science and Technology China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs National Engineering Laboratory of Animal Breeding College of Animal Science and Technology China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs National Engineering Laboratory of Animal Breeding College of Animal Science and Technology China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs National Engineering Laboratory of Animal Breeding College of Animal Science and Technology China Agricultural University 2 Yuanmingyuan West Road Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2009-2730"},{"key":"e_1_2_3_3_1","unstructured":"AguilarI. 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