{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:37:56Z","timestamp":1761766676683,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Homozygous and compound heterozygous Miniature horses for <jats:italic>ACAN<\/jats:italic> alleles <jats:italic>D1<\/jats:italic>,<jats:italic> D2<\/jats:italic>,<jats:italic> D3*<\/jats:italic> and <jats:italic>D4<\/jats:italic> exhibit chondrodysplastic dwarfism (OMIA 001271\u20109796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism\u2010causing alleles had a shorter withers height than non\u2010carriers. A total of 245 Miniature horses were tested for these four <jats:italic>ACAN<\/jats:italic> alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non\u2010carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.72E \u2212 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism\u2010causing variants may be due to selection for decreased height.<\/jats:p>","DOI":"10.1111\/age.12921","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T13:33:41Z","timestamp":1581946421000},"page":"420-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heterozygotes for <i>ACAN<\/i> dwarfism alleles in horses have reduced stature"],"prefix":"10.1111","volume":"51","author":[{"given":"K. T.","family":"Graves","sequence":"first","affiliation":[{"name":"Department of Veterinary Science MH Gluck Equine Research Center University of Kentucky Lexington KY 40546 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Eberth","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science MH Gluck Equine Research Center University of Kentucky Lexington KY 40546 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-9117","authenticated-orcid":false,"given":"E.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science MH Gluck Equine Research Center University of Kentucky Lexington KY 40546 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2017.05.008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12682"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140749"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3186-0"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039929"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056497"},{"key":"e_1_2_4_8_1","first-page":"143","article-title":"Whole\u2010genome sequencing reveals a potential causal mutation for dwarfism in the Miniature Shetland pony","volume":"8","author":"Metzger J.","year":"2016","journal-title":"Mammalian Genome"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4877-5"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.116.029645"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037282"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00100.2015"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12031"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fage.12921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/age.12921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.12921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T16:03:31Z","timestamp":1694016211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.12921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/age.12921"],"URL":"https:\/\/doi.org\/10.1111\/age.12921","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"type":"print","value":"0268-9146"},{"type":"electronic","value":"1365-2052"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"2020-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}