{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:22:53Z","timestamp":1792725773767,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The study of skin color in cattle holds both economic and scientific interest. Several ocular diseases of cattle have been associated with low pigmentation of the eyelids, including ocular squamous cell carcinoma and infectious keratoconjunctivitis, the two most common ocular diseases affecting cattle production. Although low eyelid pigmentation is a well\u2010known risk factor for various ocular diseases, the genetic and biological basis of this relationship is largely unknown. We investigated the transcriptome of eyelid skin in Hereford cattle using RNA\u2010sequencing technology. Two contrasting groups were evaluated: steers that were completely pigmented and steers with no pigmentation in both eyelids. Most of the up\u2010regulated genes in pigmented samples are directly implicated in melanogenesis and melanosome development, whereas up\u2010regulated genes in non\u2010pigmented samples are implicated in cancer development and the immune system, among other functions. Interestingly, network analysis comparing pigmented vs. non\u2010pigmented samples revealed significant differences in the co\u2010expression patterns of genes related to melanosome, pigmentation and defense response to bacteria, showing higher gene activity, greater co\u2010expression patterns and tighter co\u2010regulation mechanisms in pigmented samples. Overall, our findings indicate that bovine eyelid pigmentation depends on the expression of many genes involved not only in pigmentation and melanosome function but also related to inflammatory response, infection and tumoral pathways.<\/jats:p>","DOI":"10.1111\/age.13004","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T17:10:41Z","timestamp":1602781841000},"page":"935-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptomic analysis of eyelid pigmentation in Hereford cattle"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-2642","authenticated-orcid":false,"given":"E.","family":"Jara","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica y Mejora Animal Facultad de Veterinaria Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-3991","authenticated-orcid":false,"given":"F.","family":"Pe\u00f1agaricano","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences University of Wisconsin\u2013Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Metabolismo Animal Facultad de Veterinaria Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tardiz","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Mejora Animal Facultad de Veterinaria Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rodons","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Mejora Animal Facultad de Veterinaria Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iriarte","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Computacional Departamento de Desarrollo Biotecnol\u00f3gico Facultad de Medicina Instituto de Higiene Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-1368","authenticated-orcid":false,"given":"E.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Mejora Animal Facultad de Veterinaria Universidad de la Rep\u00fablica Montevideo 11600 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/82.1.21"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2014.11.006"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.02.001"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"a031260","DOI":"10.1101\/cshperspect.a031260","article-title":"Biology of fibroblast growth factor 23: from physiology to pathology","volume":"8","author":"Courbebaisse M.","year":"2017","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1056945"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq574"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001057"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-020-6487-2"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.19080\/JDVS.2019.09.555774"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.2527\/2005.833507x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-248"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.211.201"},{"key":"e_1_2_4_18_1","first-page":"196","article-title":"Pigmentaci\u00f3n de los p\u00e1rpados en Hereford y su relaci\u00f3n con patolog\u00edas oculares","volume":"27","author":"Tardiz L.","year":"2016","journal-title":"Journal of Basic & Applied Genetics"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1621"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00095"},{"key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2109865","article-title":"The oncogenic role of ARG1 in progression and metastasis of hepatocellular carcinoma","volume":"2018","author":"You J.","year":"2018","journal-title":"BioMed Research International"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.13004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/age.13004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.13004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:29:19Z","timestamp":1693816159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.13004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/age.13004"],"URL":"https:\/\/doi.org\/10.1111\/age.13004","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"assertion":[{"value":"2020-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}