{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:39:16Z","timestamp":1791362356481,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D15FE\u2010009"],"award-info":[{"award-number":["D15FE\u2010009"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the domestic cat with a genetic predisposition in a few breeds. In the Maine Coon and Ragdoll breeds, two variants associated with the HCM phenotype have been identified in the cardiac myosin binding protein C gene (<jats:italic>MYBPC3;<\/jats:italic> p.Ala31Pro and p.Arg820Trp respectively), and a single variant has been identified in the myosin heavy chain gene (<jats:italic>MYH7<\/jats:italic>; p.Glu1883Lys) in one domestic cat with HCM. It is not known if these variants influence the development of HCM in other cohorts of the feline population. The objective of this study was to evaluate the presence of the known <jats:italic>MYBPC3<\/jats:italic> and <jats:italic>MYH7<\/jats:italic> variants in a population of cats with HCM. DNA was isolated from samples collected from non\u2010Ragdoll and non\u2010Maine Coon domestic cats diagnosed with HCM through the North Carolina State University College of Veterinary Medicine and genotyped for the three variants. One\u2010hundred and three DNA samples from cats with HCM were evaluated from domestic shorthair, domestic longhair and purebred cats. All samples were wt for the <jats:italic>MYBPC3<\/jats:italic> and <jats:italic>MYH7<\/jats:italic> variants. Although this study was limited by its inclusion of cats from one tertiary hospital, the lack of these <jats:italic>MYBPC3<\/jats:italic> and <jats:italic>MYH7<\/jats:italic> variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. Further studies to identify the causative variants for the feline HCM population are warranted.<\/jats:p>","DOI":"10.1111\/age.13074","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T16:20:26Z","timestamp":1620663626000},"page":"542-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Absence of known feline <i>MYH7<\/i> and <i>MYBPC3<\/i> variants in a diverse cohort of cats with hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"52","author":[{"given":"K.","family":"O'Donnell","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Adin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"DeFrancesco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tou","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-3799","authenticated-orcid":false,"given":"K. M.","family":"Meurs","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine North Carolina State University A227, Main CVM, 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0113.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13743"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0751.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2015.07.003"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-4-293"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12031"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2010.06.004"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14553686"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.04.007"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0341.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi386"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01740-5"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2015.03.008"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-019-0431-4"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00906.x"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.13074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/age.13074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.13074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:24:14Z","timestamp":1692840254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.13074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/age.13074"],"URL":"https:\/\/doi.org\/10.1111\/age.13074","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"2021-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}