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An intronic variant in <jats:italic>TNNT2<\/jats:italic>, c.95\u2010108G&gt;A, was recently reported as the cause of HCM in the Maine Coon. The aim of this study was to determine this variant\u2019s allele frequency in different populations and its possible association with HCM. Based on 160 Maine Coon samples collected in Belgium, Italy, Sweden and the USA, the variant\u2019s allele frequency was estimated to be 0.32. Analysis of the 99 Lives feline whole genome sequencing database showed that the <jats:italic>TNNT2<\/jats:italic> variant also occurs in other breeds, as well as mixed\u2010breed cats. Comparison of 31 affected and 58 healthy cats did not reveal significantly increased odds for HCM in homozygotes. Based on the combined evidence and in agreement with the standards and guidelines for the interpretation of sequence variants, this variant is currently classified as a variant of unknown significance and should not be used for breeding decisions regarding HCM.<\/jats:p>","DOI":"10.1111\/age.13223","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T07:38:04Z","timestamp":1653896284000},"page":"526-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The <i>TNNT2<\/i>:c.<scp>95\u2010108G<\/scp>&gt;A variant is common in Maine Coons and shows no association with hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-3418","authenticated-orcid":false,"given":"Tom","family":"Schipper","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biosciences Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-0141","authenticated-orcid":false,"given":"\u00c5sa","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-1855","authenticated-orcid":false,"given":"Maria","family":"Longeri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica J.","family":"Hayward","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Cornell Veterinary Biobank, College of Veterinary Medicine Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Mouttham","sequence":"additional","affiliation":[{"name":"Cornell Veterinary Biobank, College of Veterinary Medicine Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Osservatorio Veterinario Italiano Cardiopatie  Azzano S. 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