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This variation is mostly based on selective breeding. During the beginning of selective breeding, potential negative consequences did not become immediately evident due to low frequencies of homozygous animals and have been occasionally neglected. However, numerous studies of coat color genetics have been carried out over more than a century and, meanwhile, pleiotropic effects for several coat color genes, including disorders of even lethal impact, were described. Similar coat color phenotypes can often be found across species, caused either by conserved genes or by different genes. Even in the same species, more than one gene could cause the same or similar coat color phenotype. The roan coat color in livestock species is characterized by a mixture of white and colored hair in cattle, pig, sheep, goat, alpaca, and horse. So far, the genetic background of this phenotype is not fully understood, but <jats:italic>KIT<\/jats:italic> and its ligand <jats:italic>KITLG<\/jats:italic> (<jats:italic>MGF<\/jats:italic>) are major candidate genes in livestock species. For some of these species, pleiotropic effects such as subfertility in homozygous roan cattle or homozygous embryonic lethality in certain horse breeds have been described. This review aims to point out the similarities and differences of the roan phenotype across the following livestock species: cattle, pig, sheep, goat, alpaca, and horse; and provides the current state of knowledge on genetic background and pleiotropic effects.<\/jats:p>","DOI":"10.1111\/age.13240","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T06:44:43Z","timestamp":1657521883000},"page":"549-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Roan coat color in livestock"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-0048","authenticated-orcid":false,"given":"Katharina","family":"Vo\u00df","sequence":"first","affiliation":[{"name":"Institute of Animal Breeding and Husbandry University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-3415","authenticated-orcid":false,"given":"Iulia","family":"Blaj","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Husbandry University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Tetens","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Husbandry University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-2039","authenticated-orcid":false,"given":"Georg","family":"Thaller","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Husbandry University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-6284","authenticated-orcid":false,"given":"Doreen","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Genome Biology Research Institute for Farm Animal Biology (FBN)  Dummerstorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102052.2000.00677.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a111454"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a107776"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a109606"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a103037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781780643298.0000"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12240"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102052.2010.02116.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/33.1.22"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/39.1.35"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2478\/aoas\u20102014\u20100066"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258\u2010010\u20100108\u20104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u2010185X.2011.00177.x"},{"key":"e_1_2_10_16_1","volume-title":"Insights into the alpaca skin transcriptome in relation to fibre colour","author":"Cransberg R.","year":"2017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2010.90333"},{"key":"e_1_2_10_18_1","volume-title":"Inheritance of fibre colour in alpacas: identifying the genes involved","author":"Feeley N.L.","year":"2015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102052.2010.02054.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2005.07.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359901178"},{"key":"e_1_2_10_22_1","first-page":"333","volume-title":"Genetic variants and strains of the laboratory mouse","author":"Green M. 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