{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:39:02Z","timestamp":1787027942517,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/23\/B\/NZ2\/01762"],"award-info":[{"award-number":["2016\/23\/B\/NZ2\/01762"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disorders of sex development (DSDs) are discrepancies between sex chromosomes and phenotypical sex. Quite common forms of DSD in canine populations include testicular and ovotesticular XX DSDs with a normal set of sex chromosomes. The objective of this study was to identify genes and putative harmful variants for canine XX DSDs. I have reanalyzed data from the whole\u2010genome sequencing of 11 XX DSD French Bulldogs and six XX DSD American Staffordshire Terriers. Identity\u2010by\u2010descent analysis revealed cryptic relatedness in affected French Bulldogs. Causative genes were sought in chromosomal segments shared identical\u2010by\u2010descent by close relatives. In French Bulldogs, the reanalysis identified 19 regions of importance with a total length of just 65.9\u00a0Mb. Variant filtering within the regions implicated <jats:italic>AKAP2<\/jats:italic>, <jats:italic>PIWIL1<\/jats:italic>, <jats:italic>POLR3A<\/jats:italic> and <jats:italic>SH2D4B<\/jats:italic> as genes that may be involved in individual cases of testicular and ovotesticular XX DSD in French Bulldogs and American Staffordshire Terriers.<\/jats:p>","DOI":"10.1111\/age.13276","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T08:01:52Z","timestamp":1669622512000},"page":"166-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A clue to the etiology of disorders of sex development from identity\u2010by\u2010descent analysis in dogs with cryptic relatedness"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-5173","authenticated-orcid":false,"given":"Maciej","family":"Szydlowski","sequence":"first","affiliation":[{"name":"Department of Genetics 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