{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:47:17Z","timestamp":1791910037903,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_200354"],"award-info":[{"award-number":["310030_200354"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ichthyoses represent a heterogeneous group of cornification disorders that are associated with skin barrier defects. We investigated a 9\u2010month\u2010old Chihuahua showing excessive scale formation. Clinical and histopathological examinations revealed non\u2010epidermolytic ichthyosis and a genetic defect was suspected. We therefore sequenced the genome of the affected dog and compared the data with 564 genetically diverse control genomes. Filtering for private variants identified a homozygous missense variant in <jats:italic>SDR9C7<\/jats:italic>, c.454C&gt;T or p.(Arg152Trp). <jats:italic>SDR9C7<\/jats:italic> is a known candidate gene for ichthyosis in humans and encodes the short\u2010chain dehydrogenase\/reductase family 9C member 7. The enzyme is involved in the production of a functional corneocyte lipid envelope (CLE), a crucial component of the epidermal barrier. Pathogenic variants in <jats:italic>SDR9C7<\/jats:italic> have been described in human patients with autosomal recessive ichthyosis. We assume that the identified missense variant in the affected Chihuahua of this study impairs the normal enzymatic activity of SDR9C7 and thus prevents the formation of a functioning CLE, resulting in a defective skin barrier. To the best of our knowledge, this is the first report of a spontaneous <jats:italic>SDR9C7<\/jats:italic> variant in domestic animals.<\/jats:p>","DOI":"10.1111\/age.13319","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:57:03Z","timestamp":1679900223000},"page":"562-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>SDR9C7<\/i> missense variant in a Chihuahua with non\u2010epidermolytic ichthyosis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-2370","authenticated-orcid":false,"given":"Sarah","family":"Kiener","sequence":"first","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty University of Bern  Bern Switzerland"},{"name":"DermFocus University of Bern  Bern 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