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We characterised SNPs associated with behaviour in yearling Thoroughbred horses using genomics analyses for two phenotypes: (1) handler\u2010assessed coping with early training events [coping] (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a096); and (2) variation in salivary cortisol concentration at the first backing event [cortisol] (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a034). Using RNA\u2010seq derived gene expression data for amygdala and hippocampus tissues from\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02 Thoroughbred stallions, we refined the SNPs to those with functional relevance to behaviour by cross\u2010referencing to the 500 most highly expressed genes in each tissue. The SNPs of high significance (\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.01) were in proximity to genes (coping \u2013\n                    <jats:italic>GABARAP<\/jats:italic>\n                    ,\n                    <jats:italic>NDM<\/jats:italic>\n                    ,\n                    <jats:italic>OAZ1<\/jats:italic>\n                    ,\n                    <jats:italic>RPS15A<\/jats:italic>\n                    ,\n                    <jats:italic>SPARCL1<\/jats:italic>\n                    ,\n                    <jats:italic>VAMP2<\/jats:italic>\n                    ; cortisol \u2013\n                    <jats:italic>CEBPA<\/jats:italic>\n                    ,\n                    <jats:italic>COA3<\/jats:italic>\n                    ,\n                    <jats:italic>DUSP1<\/jats:italic>\n                    ,\n                    <jats:italic>HNRNPH1<\/jats:italic>\n                    ,\n                    <jats:italic>RACK1<\/jats:italic>\n                    ) with biological functions in social behaviour, autism spectrum disorder, suicide, stress\u2010induced anxiety and depression, Alzheimer's disease, neurodevelopmental disorders, neuroinflammatory disease, fear\u2010induced behaviours and alcohol and cocaine addiction. The strongest association (\n                    <jats:italic>q<\/jats:italic>\n                    \u00a0=\u00a00.0002) was with\n                    <jats:italic>NDN<\/jats:italic>\n                    , a gene previously associated with temperament in cattle. This approach highlights functionally relevant genes in the behavioural adaptation of Thoroughbred horses that will contribute to the development of genetic markers to improve racehorse welfare.\n                  <\/jats:p>","DOI":"10.1111\/age.13320","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:09:43Z","timestamp":1679897383000},"page":"457-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Integrative genomics analysis highlights functionally relevant genes for equine behaviour"],"prefix":"10.1111","volume":"54","author":[{"given":"Amy R.","family":"Holtby","sequence":"first","affiliation":[{"name":"Plusvital Ltd, The Highline, Dun Laoghaire Industrial Estate  Dublin Ireland"},{"name":"UCD School of Agriculture and Food Science, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hall","sequence":"additional","affiliation":[{"name":"UCD School of Agriculture and Food Science, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice A.","family":"McGivney","sequence":"additional","affiliation":[{"name":"Plusvital Ltd, The Highline, Dun Laoghaire Industrial Estate  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haige","family":"Han","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center Inner Mongolia Agricultural University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center Inner Mongolia Agricultural University  Hohhot China"},{"name":"UCD School of Biomolecular and Biomedical Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"MacHugh","sequence":"additional","affiliation":[{"name":"Plusvital Ltd, The Highline, Dun Laoghaire Industrial Estate  Dublin Ireland"},{"name":"UCD Conway Institute of Biomolecular and Biomedical Research University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Katz","sequence":"additional","affiliation":[{"name":"UCD School of Agriculture and Food Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-2250","authenticated-orcid":false,"given":"Emmeline W.","family":"Hill","sequence":"additional","affiliation":[{"name":"Plusvital Ltd, The Highline, Dun Laoghaire Industrial Estate  Dublin Ireland"},{"name":"UCD School of Agriculture and Food Science, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb02462.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3891"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10091513"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135647100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00027.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058679"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32434"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/521987"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9060363"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050331"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60341-5"},{"key":"e_1_2_11_13_1","unstructured":"Carlson M.(2019)GO.db: a set of annotation maps describing the entire gene ontology. 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