{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:02:34Z","timestamp":1793739754263,"version":"4.6.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematological traits are important indicators of health status, and they are frequently used as criteria for clinical diagnosis. In humans, the genomic architecture of blood traits has been investigated in depth and thousands of associations with genetic variants have been found. In contrast, the association between marker genotypes and the variation of hematological traits has not been investigated in goats yet. Herewith, we have recorded 12 hematological parameters in 882 Murciano\u2010Granadina goats that were also genotyped with the Goat SNP50 BeadChip (Illumina). Performance of a univariate genome\u2010wide association study (GWAS) made it possible to detect one genomic region on goat chromosome (CHI) 21 (19.2\u201319.5\u2009Mb) associated, at the genome\u2010wide level of significance, with 4 red blood cell traits. The three markers displaying the highest significances were rs268272996 (CHI21: 19225290\u2009bp), rs268273004 (CHI21: 19565629\u2009bp) and rs268239059 (CHI13: 9615190\u2009bp). Consistently, a multivariate GWAS indicated that the rs268273004 marker on chromosome 21 is associated with seven blood cell traits. Interestingly, this marker maps close to the FA Complementation Group I (<jats:italic>FANCI<\/jats:italic>) gene (CHI21: 20021947\u201320077025\u2009bp), which is functionally related to Fanconi anemia, a syndrome characterized by bone marrow failure, aplastic anemia, and congenital disorders. We have also uncovered additional chromosome\u2010wide significant associations between genetic markers and erythrocyte and leukocyte traits in the univariate GWAS. These findings evidence that the phenotypic variation of hematological traits in goats is regulated, at least to some extent, by polygenic determinants distributed in multiple chromosomes.<\/jats:p>","DOI":"10.1111\/age.13328","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:25:00Z","timestamp":1682987100000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Univariate and multivariate genome\u2010wide association studies for hematological traits in <scp>Murciano\u2010Granadina<\/scp> goats"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-384X","authenticated-orcid":false,"given":"Martina","family":"Macri","sequence":"first","affiliation":[{"name":"Animal Breeding Consulting S.L. Parque Cient\u00edfico Tecnol\u00f3gico de C\u00f3rdoba  C\u00f3rdoba Spain"},{"name":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba Campus Universitario de Rabanales  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-0550","authenticated-orcid":false,"given":"Maria Gracia","family":"Luigi\u2010Sierra","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC\u2010IRTA\u2010UAB\u2010UB, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-3158","authenticated-orcid":false,"given":"Dailu","family":"Guan","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC\u2010IRTA\u2010UAB\u2010UB, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1657-8838","authenticated-orcid":false,"given":"Juan Vicente","family":"Delgado","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba Campus Universitario de Rabanales  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Fern\u00e1ndez","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Nacional de Criadores de Caprino de Raza Murciano\u2010Granadina (CAPRIGRAN)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-0770","authenticated-orcid":false,"given":"Marcel","family":"Amills","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC\u2010IRTA\u2010UAB\u2010UB, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Departament de 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