{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:31:48Z","timestamp":1781875908724,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["BI\u2010DE\/20\u201021\u2010003"],"award-info":[{"award-number":["BI\u2010DE\/20\u201021\u2010003"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["DAAD ID\u201057418683"],"award-info":[{"award-number":["DAAD ID\u201057418683"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["DAAD ID\u201057514909"],"award-info":[{"award-number":["DAAD ID\u201057514909"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ear length in sheep (<jats:italic>Ovis aries<\/jats:italic>) shows a wide range of natural variation, from the absence of an outer ear structure (<jats:italic>anotia<\/jats:italic>), to small outer ears (<jats:italic>microtia<\/jats:italic>), to regular ear length. Up until now, the underlying genetics of this phenotype has been studied in four sheep breeds from China, Jordan and Italy. These studies revealed a broad range of genes significantly associated with ear length, potentially indicating genetic heterogeneity across breeds or geographic regions. In the current study, we performed genome\u2010wide SNP genotyping and haplotype\u2010based mapping, in a population of 340 individuals, to identify loci influencing ear length variation in additional sheep breeds from Slovenia, Croatia, Cyprus and Greece. Additionally, two previously described candidate variants were also genotyped in our mapping population. The mapping model without candidate variant genotypes revealed only one genome\u2010wide significant signal, which was located next to <jats:italic>HMX1<\/jats:italic> on OAR6. This region was previously described as being associated with ear length variation in the Altay and Awassi sheep breeds. The mapping model including the candidate duplication genotype near <jats:italic>HMX1<\/jats:italic> as a fixed effect explained the phenotypic variance on OAR6 and revealed an additional genome\u2010wide significant locus on OAR13 associated with ear length. Our results, combined with published evidence, suggest that a duplication in the evolutionarily conserved region near <jats:italic>HMX1<\/jats:italic> is the major regulator of ear length in sheep breeds descended from a larger region from Central Asia, to the Middle East, Cyprus, Greece and to the Alps. This distribution suggests an ancient origin of the derived allele.<\/jats:p>","DOI":"10.1111\/age.13387","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T06:50:22Z","timestamp":1702104622000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic basis of ear length in sheep breeds sampled across the region from the Middle East to the Alps"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5244-7276","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Klawatsch","sequence":"first","affiliation":[{"name":"Population Genomics Group, Department of Veterinary Sciences Ludwig Maximillians University Munich  Munich Germany"},{"name":"Tierzuchtforschung e.V. Munich  Grub Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Papachristou","sequence":"additional","affiliation":[{"name":"Department of Animal Science Agricultural University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Koutsouli","sequence":"additional","affiliation":[{"name":"Department of Animal Science Agricultural University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulik","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Population Genomics Group, Department of Veterinary Sciences Ludwig Maximillians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Seichter","sequence":"additional","affiliation":[{"name":"Tierzuchtforschung e.V. 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Munich  Grub Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boro","family":"Mio\u010d","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, Faculty of Agriculture University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojca","family":"Sim\u010di\u010d","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biotechnical Faculty University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosif","family":"Bizelis","sequence":"additional","affiliation":[{"name":"Department of Animal Science Agricultural University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-3039","authenticated-orcid":false,"given":"Ivica","family":"Medugorac","sequence":"additional","affiliation":[{"name":"Population Genomics Group, Department of Veterinary 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