{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:06:37Z","timestamp":1767920797066,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019227","name":"Foundation of Jiangxi Educational Commission","doi-asserted-by":"publisher","award":["GJJ180816"],"award-info":[{"award-number":["GJJ180816"]}],"id":[{"id":"10.13039\/501100019227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019227","name":"Foundation of Jiangxi Educational Commission","doi-asserted-by":"publisher","award":["GJJ2201456"],"award-info":[{"award-number":["GJJ2201456"]}],"id":[{"id":"10.13039\/501100019227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polydactyly is a genetic abnormality that affects both pig welfare and industry profits. Despite efforts to explore the genetic basis of pig polydactyly, progress remains limited. In this study, we analyzed a group of Large White pigs with postaxial polydactyly, including 29 cases and 79 controls from 24 families. High\u2010depth sequencing was performed on 20 pigs, while low\u2010depth sequencing was improved through imputation for the remaining pigs. A genome\u2010wide association study (GWAS) and genetic differentiation were conducted using the resequencing dataset, resulting in the identification of 48 significantly associated SNPs and 27 candidate regions. The genetic differentiation regions on chromosomes 5 and 18, which harbored GWAS\u2010identified SNPs, were delineated as confidence regions. The confidence region at Chr18: 1.850\u20131.925\u2009Mb covers the fifth intron of <jats:italic>LMBR1<\/jats:italic>, a gene that contains an important regulatory element for <jats:italic>SHH<\/jats:italic>, known as ZRS. Mutations in this ZRS have been found to cause polydactyly in animals and humans. Therefore, we propose <jats:italic>LMBR1<\/jats:italic> as a prospective candidate gene for postaxial polydactyly. These findings emphasize the importance of exploring the role of ZRS within <jats:italic>LMBR1<\/jats:italic> in the pathogenesis of polydactyly in pigs.<\/jats:p>","DOI":"10.1111\/age.13399","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:28:57Z","timestamp":1706516937000},"page":"277-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Whole genome resequencing reveals candidate genes for postaxial polydactyly in Large White pigs"],"prefix":"10.1111","volume":"55","author":[{"given":"Yongle","family":"Hao","sequence":"first","affiliation":[{"name":"Laboratory Animal Engineering Research Center of Ganzhou Gannan Medical University  Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlei","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory Animal Engineering Research Center of Ganzhou Gannan Medical University  Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory Animal Engineering Research Center of Ganzhou Gannan Medical University  Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-5542","authenticated-orcid":false,"given":"Jianhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Engineering Research Center of Ganzhou Gannan Medical University  Jiangxi 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