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Thus, understanding its genetic basis is essential. This study identified four birth weight\u2010associated genomic regions on chromosomes 2, 4, 5, and 7 through genome\u2010wide association study analysis in 7286 pigs from three different pure breeds using the FarmCPU model. The genetic and phenotypic variance explained by the four candidate regions is 8.42% and 1.85%, respectively. Twenty\u2010eight candidate genes were detected, of which <jats:italic>APPL2<\/jats:italic>, <jats:italic>TGFBI<\/jats:italic>, <jats:italic>MACROH2A1<\/jats:italic>, and <jats:italic>SEC22B<\/jats:italic> have been reported to affect body growth or development. In addition, 21 H3K4me3\u2010enriched peaks overlapped with the birth weight\u2010associated genomic regions were identified by integrating the genome\u2010wide association study results with our previous ChIP\u2010seq and RNA\u2010seq data generated in the pig placenta, a fetal organ relevant to birth weight, and three of the regulatory regions influence <jats:italic>TGFBI<\/jats:italic>, <jats:italic>MACROH2A1<\/jats:italic>, and <jats:italic>SEC22B<\/jats:italic> expression. This study provides new insights into understanding the mechanisms for birth weight. Further investigating the variants in the regulatory regions would help identify the functional variants for birth weight in pigs.<\/jats:p>","DOI":"10.1111\/age.13468","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T11:18:46Z","timestamp":1723547926000},"page":"761-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A genome\u2010wide association study reveals candidate genes and regulatory regions associated with birth weight in pigs"],"prefix":"10.1111","volume":"55","author":[{"given":"Dadong","family":"Deng","sequence":"first","affiliation":[{"name":"Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction Ministry of Education, College of Animal Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key 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