{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:07:51Z","timestamp":1782860871203,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2452020187"],"award-info":[{"award-number":["2452020187"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rabbits display a wide range of coat colors, with yellow being a particular phenotype that aids in exploring the molecular mechanisms of coat pigmentation. The Fujian yellow (FJY) rabbit, as China's only indigenous breed with a yellow coat, serves as a valuable genetic resource. Fujian yellow rabbits have predominantly yellow fur, with a diluted white hue on the distal limbs and tail. However, the genetic mechanism underlying yellow coat color remains unclear. To address this, we conducted selection signature analysis to identify candidate genes and potential casual mutations underlying the yellow phenotype in rabbits. Utilizing whole\u2010genome resequencing, a total of 22\u2009486\u2009177 high\u2010quality SNPs were identified from 30 individuals belonging to three Chinese indigenous rabbit breeds featured with yellow or non\u2010yellow phenotype. The results revealed that the <jats:italic>ASIP<\/jats:italic> gene on chromosome 4 and the <jats:italic>SNAI2<\/jats:italic> gene on chromosome 3 were under strong selection pressure, both of which play pivotal roles in determining coat color phenotypes. The <jats:italic>ASIP<\/jats:italic> gene is involved in melanogenesis across various livestock species, while the <jats:italic>SNAI2<\/jats:italic> gene is linked to hypopigmentation in the distal regions such as the limbs and tail. We further identified two SNP variants, g.23870943C&gt;T in the fourth intron of the <jats:italic>ASIP<\/jats:italic> gene, which is closely associated with the yellow phenotype, and g.73725380A&gt;G downstream of the <jats:italic>SNAI2<\/jats:italic> gene, probably contributing to the white shading in Fujian yellow rabbits\u2019 limb and tail regions. These variants are key determinants in the development of the yellow coat color in rabbits. These findings advance the understanding of coat color pigmentation in domestic animals.<\/jats:p>","DOI":"10.1111\/age.70006","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:15:50Z","timestamp":1741752950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Two novel <scp>SNP<\/scp> variants at <scp><i>ASIP<\/i><\/scp> and <scp><i>SNAI2<\/i><\/scp> genes are associated with yellow coat color in rabbits"],"prefix":"10.1111","volume":"56","author":[{"given":"Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Ping","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahamba Ifeanyi","family":"Solomon","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9787-3390","authenticated-orcid":false,"given":"Xianggui","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling 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