{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:48:38Z","timestamp":1774939718224,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Guppy (\n                    <jats:italic>Poecilia reticulata<\/jats:italic>\n                    ) is a popular tropical ornamental fish with high phenotypic diversity. This study investigates the genetic basis of the red\u2010eyed trait (ocular albinism) in guppy through hybridization between the sky\u2010blue strain (red\u2010eyed) and the red\u2010fun strain (black\u2010eyed). Our results demonstrated black eye to be the dominant trait relative to red eye, and that the ratio of the number of black\u2010eyed guppies to that of red\u2010eyed ones in the F2 generation is consistent with 3:1, which indicates that the red\u2010eyed trait in the sky\u2010blue strain guppies conforms to the model of Mendelian monogenic inheritance. To identify candidate genes associated with the red\u2010eyed trait in guppies, we conducted a genome\u2010wide association study using 65 F2 individuals (23 red\u2010eyed and 42 black\u2010eyed). A total of 106 genes showed significant associations with the red\u2010eyed trait in guppy and\n                    <jats:italic>OCA2<\/jats:italic>\n                    was considered as the most important candidate gene. This study provides a reference for insights into the molecular mechanisms underlying ocular albinism in guppy.\n                  <\/jats:p>","DOI":"10.1111\/age.70045","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:43:17Z","timestamp":1759905797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A genome\u2010wide association study for the red\u2010eyed trait (ocular albinism) in an\n                    <scp>F2<\/scp>\n                    population of guppy (\n                    <i>Poecilia reticulata<\/i>\n                    )"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7900-8978","authenticated-orcid":false,"given":"Ying","family":"Chang","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenjun","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-3957","authenticated-orcid":false,"given":"Haigang","family":"Bao","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxin","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-176"},{"key":"e_1_2_6_4_1","volume-title":"StatPearls","author":"Federico J.R.","year":"2024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-43"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2337-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083118-015230"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.220235"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2010.126"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183318"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2194-7"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/age.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:11:52Z","timestamp":1761145912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/age.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/age.70045"],"URL":"https:\/\/doi.org\/10.1111\/age.70045","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70045"}}