{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:45:19Z","timestamp":1761180319001,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Three colors of Dexter cattle are currently recognized: black, red, and dun. In Dexters, dun is determined by a recessive genotype of\n                    <jats:italic>TYRP1<\/jats:italic>\n                    (b\/b) that dilutes an otherwise black animal (\n                    <jats:italic>MC1R<\/jats:italic>\n                    genotype ED\/\u2212); this variant does not impact red cattle. A subset of Dexters with dilute coat colors described as dark dun\/chocolate (CD) or light dun\/cream (CL) were identified. Although phenotypically similar to dun, they did not have the expected\n                    <jats:italic>TYRP1<\/jats:italic>\n                    b\/b genotype. Given relationships among the reported individuals, we hypothesized that a novel recessive genotype is causative of CD on a black background and CL on a red background. Whole\u2010genome sequence was generated from four dilute Dexters (three CD and one CL), and one black calf of a CD dam. None of the cattle sequenced had the\n                    <jats:italic>TYRP1<\/jats:italic>\n                    b\/b genotype. The comparison of variants in the five Dexter cattle to those from 226 non\u2010Dexter control cattle resulted in the identification of a missense variant in\n                    <jats:italic>SLC45A2<\/jats:italic>\n                    (NC_037347.1: g.39790189A&gt;C; XM_002696386.6: c.398A&gt;C) that fit the proposed hypothesis. Sanger sequencing of additional Dexter cattle (\n                    <jats:italic>n<\/jats:italic>\n                    =\u2009227) demonstrated complete segregation of the recessive genotype with the CD and CL phenotypes. The mutation, predicted to result in a substitution of glutamine with proline (XP_002696432.2: p.Gln133Pro) in a transmembrane helix was classified as deleterious by SIFT. Further supporting its implication,\n                    <jats:italic>SLC45A2<\/jats:italic>\n                    is responsible for coat color dilutions and oculocutaneous albinism type IV in multiple species. Testing for the\n                    <jats:italic>SLC45A2<\/jats:italic>\n                    variant can be a valuable resource for Dexter breeders interested in coat color.\n                  <\/jats:p>","DOI":"10.1111\/age.70054","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:13:36Z","timestamp":1760663616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A recessive coat color dilution in Dexter cattle attributed to a missense mutation in\n                    <i>SLC45A2<\/i>"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-2850","authenticated-orcid":false,"given":"Anna M.","family":"Fuller","sequence":"first","affiliation":[{"name":"Department of Animal Science University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Davidson","sequence":"additional","affiliation":[{"name":"Vancouver Island  British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-8555","authenticated-orcid":false,"given":"Jessica L.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5251"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2052.2003.00985.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.2.694"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129273"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040583"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12080"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"76","article-title":"Fate of melanocytes during development of the hair follicle Pigmentary unit","volume":"8","author":"Botchkareva N.V.","year":"2003","journal-title":"The Society for Investigative Dermatology, Inc"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2009.01850.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12582"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110229200"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1038"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","unstructured":"Hallgren J. 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