{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:25:12Z","timestamp":1759937112304},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Oxytocin (<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>) and protein kinase A (<jats:styled-content style=\"fixed-case\">PKA<\/jats:styled-content>), a possible intracellular mediator of hormone action in the ovary, can be potent activators of ovarian functions and fertility. Nevertheless, action of <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content> on ovarian follicle atresia has not been studied yet. Only single administration of <jats:styled-content style=\"fixed-case\">PKA<\/jats:styled-content> activators [3\u2010isobutyl\u20101\u2010methyl\u2010xanthine (<jats:styled-content style=\"fixed-case\">IBMX<\/jats:styled-content>) and dibutyryl cyclic adenosine monophosphate (dbc<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>)] on ovarian follicle atresia was studied previously. The aim of this study was to examine the effect of <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content> (single treatment per one reproductive cycle, multiple treatments for three cycles), <jats:styled-content style=\"fixed-case\">IBMX<\/jats:styled-content> and dbc<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> (multiple treatments) on folliculogenesis and follicular atresia in rabbit. The ovarian cycle in control females was induced only by gonadotropins. Experimental females received co\u2010administration of gonadotropins with <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IBMX<\/jats:styled-content> or dbc<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> (at 50\u00a0\u03bcg\/female). All females were artificially inseminated. Single\u2010treated females were euthanized after 18\u201319\u00a0h. Multiple\u2010treated females were euthanized after the third reproductive cycle. Histological sections of the ovaries were prepared and evaluated by a light microscopy. The follicles were divided into four classes according to the structure of granulosa and theca cells as follows: none or small atresia, cystic atresia, obliterative atresia and atresia associated with luteinization. The ovaries from the control and experimental females, treated during one reproductive cycle or three cycles, were compared. Single <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content> co\u2010administration increased proportion of follicles with atresia associated with luteinization, but not other types of atresia. No influence of multiple <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content> co\u2010administration on follicular atresia was recorded. Multiple <jats:styled-content style=\"fixed-case\">IBMX<\/jats:styled-content> and dbc<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> co\u2010administration decreased the proportion of atretic follicles and increased the proportion of healthy follicles without atresia.<\/jats:p>","DOI":"10.1111\/ahe.12088","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:17:54Z","timestamp":1381544274000},"page":"379-385","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Oxytocin, <scp>IBMX<\/scp> and dbc<scp>AMP<\/scp> on Rabbit Ovarian Follicles"],"prefix":"10.1111","volume":"43","author":[{"given":"A.","family":"Balazi","sequence":"first","affiliation":[{"name":"Institute of Animal Genetics and Reproduction Animal Production Research Centre Nitra Hlohoveck\u00e1 2 951 41 Lu\u017eianky Slovak Republic"},{"name":"Department of Biochemistry and Biotechnology Faculty of Biotechnology and Food Sciences Slovak University of Agriculture in Nitra Tr. A. Hlinku 2 949 76 Nitra Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Sirotkin","sequence":"additional","affiliation":[{"name":"Institute of Animal Genetics and Reproduction Animal Production Research Centre Nitra Hlohoveck\u00e1 2 951 41 Lu\u017eianky Slovak Republic"},{"name":"Department of Zoology and Anthropology Constantine the Philosopher University N\u00e1bre\u017eie ml\u00e1de\u017ee 91 949 74 Nitra Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pivko","sequence":"additional","affiliation":[{"name":"Institute of Animal Genetics and Reproduction Animal Production Research Centre Nitra Hlohoveck\u00e1 2 951 41 Lu\u017eianky Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chrenek","sequence":"additional","affiliation":[{"name":"Institute of Animal Genetics and Reproduction Animal Production Research Centre Nitra Hlohoveck\u00e1 2 951 41 Lu\u017eianky Slovak Republic"},{"name":"Department of Biochemistry and Biotechnology Faculty of Biotechnology and Food Sciences Slovak University of Agriculture in Nitra Tr. 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