{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T16:15:15Z","timestamp":1695831315989},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500807"],"award-info":[{"award-number":["81500807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Transforming growth factor\u2010\u03b21 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21) plays several crucial regulatory roles in multiple physiological and pathological processes. The aim of this work was to investigate the role of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 in branching morphogenesis of salivary gland. We harvested and cultured submandibular salivary glands (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s) from murine embryos, which were then treated with exogenous <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21, or its neutralized antibody, Smad3 inhibitor, or Smad3 small interfering <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>). Our results suggested that <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 attenuated branching morphogenesis of embryonic murine <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> via Smad3 activation, thus playing a negative regulatory role in salivary gland development.<\/jats:p>","DOI":"10.1111\/ahe.12295","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T02:32:48Z","timestamp":1504837968000},"page":"600-605","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TGF<\/scp>\u2010\u03b21 attenuated branching morphogenesis of embryonic murine submandibular gland through Smad3 activation"],"prefix":"10.1111","volume":"46","author":[{"given":"P.","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Head and Neck Oncology West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010H.","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Head and Neck Oncology West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010M.","family":"Gou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Head and Neck Oncology West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Sichuan Provincial Hospital University of Electronic Science and Technology  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.\u2010H.","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese and Western Medicine Hospital of Panzhihua  Panzhihua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010J.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Head and Neck Oncology West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Head and Neck Oncology West China Hospital of Stomatology Sichuan University  Chengdu 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