{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:40:18Z","timestamp":1783489218307,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. The testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections. Thus, this study aimed to immunohistochemically demonstrate the distribution and localization of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68\u2010, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010, <jats:styled-content style=\"fixed-case\">MHCI<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">MHCII<\/jats:styled-content>\u2010positive immune cells in the testes and epididymes. Negative immunoreactivity was detected in the seminiferous tubule epithelium and peritubular myoid cells of the testes upon staining in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> Class I. Positive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68 immunoreaction was determined in the Sertoli cells and some Leydig cells. The detection of positive cells for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 clearly indicated the presence of lymphocytes. Furthermore, the staining with <jats:styled-content style=\"fixed-case\">MHCI<\/jats:styled-content> intensity was ascertained to vary from weak to moderate in the Sertoli and Leydig cells and connective tissue cells. <jats:styled-content style=\"fixed-case\">MHCII<\/jats:styled-content>\u2010positive immunoreactivity was determined in myoid cells and Leydig cells in the interstitial area. The epithelium of the epididymis showed positive staining for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8, but the stroma displayed a rather weak staining. In the ram epididymis, neither intraepithelial nor interstitial positive reaction was observed for <jats:styled-content style=\"fixed-case\">MHCI<\/jats:styled-content>. In the epididymis, the basal cells displayed a stronger staining for <jats:styled-content style=\"fixed-case\">MHCII<\/jats:styled-content>. In conclusion, these cells not only contribute to local immunity through their direct effects on the quality of fertility in males, but also contribute either directly or indirectly to immune privilege by minimizing the development of both autoimmune reactions and potentially harmful risks.<\/jats:p>","DOI":"10.1111\/ahe.12354","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T05:22:36Z","timestamp":1520832156000},"page":"313-321","source":"Crossref","is-referenced-by-count":5,"title":["Distribution of <scp>CD<\/scp>68\u2010, <scp>CD<\/scp>8\u2010, <scp>MHCI<\/scp>\u2010 and <scp>MHCII<\/scp>\u2010positive cells in the bull and ram testis and epididymis"],"prefix":"10.1111","volume":"47","author":[{"given":"B.","family":"G\u00fcney Saruhan","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sa\u011fs\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Akbal\u0131k","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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