{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:42:44Z","timestamp":1790037764644,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>3\u2032\u2010deoxy\u20103\u2032\u2010[<jats:sup>18<\/jats:sup>F]fluorothymidine (<jats:sup>18<\/jats:sup>FLT) is a radiopharmaceutical tracer used with positron emission tomography (PET), often in combination with computed tomography (CT), to image DNA synthesis, and thus, cellular proliferation. Characteristic accumulation of the tracer within haematopoietic bone marrow provides a noninvasive means to assess marrow activity and distribution throughout the living animal. The present study utilizes three\u2010dimensional analysis of <jats:sup>18<\/jats:sup>FLT\u2010PET\/CT scans to quantify the relative skeletal distribution of active marrow by anatomic site in the dog. Scans were performed on six healthy, adult (3\u20136\u00a0years of age), mixed\u2010breed dogs using a commercially available PET\/CT scanner consisting of a 64\u2010slice helical CT scanner combined with an integrated four ring, high\u2010resolution LSO PET scanner. Regions of interest encompassing 11 separate skeletal regions (skull, cervical vertebral column, thoracic vertebral column, lumbar vertebral column, sacrum, ribs, sternum, scapulae, proximal humeri, ossa coxarum, and proximal femora) were manually drawn based on CT images and thresholded by standardized uptake value to delineate bone marrow activity. Activity within each skeletal region was then divided by the total skeletal activity to derive the per cent of overall marrow activity within an individual site. The majority of proliferative marrow was located within the vertebral column. Of the sites traditionally accessed clinically for marrow sampling, the proximal humerus contained the largest percentage, followed by the ossa coxarum, proximal femur, and sternum, respectively. This information may be used to guide selection of traditional marrow sampling sites as well as inform efforts to spare important sites of haematopoiesis in radiation therapy planning.<\/jats:p>","DOI":"10.1111\/ahe.12410","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T05:39:29Z","timestamp":1540359569000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relative skeletal distribution of proliferating marrow in the adult dog determined using 3\u2032\u2010deoxy\u20103\u2032\u2010[<sup>18<\/sup>F]fluorothymidine"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-6946","authenticated-orcid":false,"given":"Joshua A.","family":"Rowe","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Morandi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin R.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Wall","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Kennel","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Reed","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Tennessee Knoxville Tennessee"},{"name":"Graduate School of Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"issue":"10","key":"e_1_2_6_2_1","first-page":"1592","article-title":"18F\u2010FLT PET in hematologic disorders: A novel technique to analyze the bone marrow compartment","volume":"47","author":"Agool A.","year":"2006","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31820aa1a1"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"1473","article-title":"Microfluidic synthesis of [18F]FLT","volume":"51","author":"Akula M.","year":"2010","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04071.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2008.00402.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2006.00132.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.055335"},{"issue":"12","key":"e_1_2_6_9_1","first-page":"3331","article-title":"3\u2010deoxy\u20103\u2010[18F]fluorothymidine\u2010positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules","volume":"62","author":"Buck A. 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