{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:19Z","timestamp":1747182919793,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The morphology of the pancreatic duct system did not receive much attention as compared to the microanatomy of the exocrine and endocrine pancreas. The histological peculiarities of the excretory duct system are of major importance especially in laboratory animals like guinea pigs. The paper describes the histological peculiarities of the major interlobular and extrapancreatic ducts in guinea pigs. The pancreatic tissue samples were collected from five guinea pigs. For histological investigation, several pancreatic fragments underwent fixation in 10% buffered formalin and were later processed by the standard paraffin technique. Subsequentially, tissue sections were stained by Goldner's trichrome staining. The mucous substances were assessed by Alcian blue and Periodic acid\u2013Schiff staining methods. The interlobular and main pancreatic ducts in the guinea pig present a simple columnar epithelium surrounded by a thick layer of dense connective tissue. The aforementioned epithelium of the main pancreatic ducts includes principal cells, goblet cells and basal cells. Additionally, the ductal epithelium presents occasional unicellular multiloculated intraepithelial mucous glands and prominent extraepithelial glands. The latter adopts a simple or compound tubular feature. The mucus elaborated by the three glandular types is mostly neutral in goblet cells, predominantly acidic in extraepithelial ductal glands, and a similar amount of acidic and neutral mucin in intraepithelial glands. In conclusion, the epithelium\u2010associated mucous glands in the interlobular and main pancreatic ducts in the guinea pig are restricted not only to goblet cells. A substantial mucous discharge probably with a protecting role against irritative pancreatic juice derives from the main ductal intraepithelial and extraepithelial glands.<\/jats:p>","DOI":"10.1111\/ahe.12625","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T07:00:57Z","timestamp":1602658857000},"page":"266-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glandular structures in the major interlobular and extrapancreatic ducts in the guinea pig"],"prefix":"10.1111","volume":"50","author":[{"given":"Adrian Florin","family":"Gal","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Histology and Embryology Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasile","family":"Rus","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Histology and Embryology Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-4945","authenticated-orcid":false,"given":"Cristian","family":"Martonos","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurel","family":"Damian","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalma","family":"Pivariu","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Chende","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viorel","family":"Micl\u0103u\u0219","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Histology and Embryology Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"volume-title":"AVMA guidelines for the Euthanasia of animals: 2020 Edition","year":"2020","author":"American Veterinary Medical Association","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(78)80055-5"},{"key":"e_1_2_9_4_1","first-page":"865","article-title":"Langerhans cells in the epithelium of main pancreatic ducts","volume":"15","author":"B\u00f6ck P.","year":"1983","journal-title":"Journal of Submicroscopic Cytology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970601)37:5\/6<407::AID-JEMT5>3.0.CO;2-A"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492768"},{"key":"e_1_2_9_7_1","first-page":"221","article-title":"Structure and function of the biliary and pancreatic tracts of the sheep","volume":"115","author":"Gemmell R. 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Pancreapedia: The Exocrine Pancreas Knowledge Base.https:\/\/doi.org\/10.3998\/panc.2014.3","DOI":"10.3998\/panc.2014.3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198908000-00013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970601)37:5\/6<384::AID-JEMT3>3.0.CO;2-E"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.37.245"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0869-0_13"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092320209"},{"key":"e_1_2_9_15_1","first-page":"277","article-title":"Cellules canalaires et oncocytes dans le pancreas humain. \u00c9tude compar\u00e9e \u00e0 l\u2019\u00e9tat normal et dans les pancr\u00e9atites chroniques","volume":"18","author":"Tasso F.","year":"1973","journal-title":"Annales D\u2019anatomie Pathologique"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144676"},{"key":"e_1_2_9_17_1","first-page":"37","article-title":"Die Feinstruktur des Epithels der Hauptausfu\u00a8hrungsga\u00a8nge der Leber und des Pankreas vom Haushuhn","volume":"143","author":"Weyrauch K. D.","year":"1978","journal-title":"Anatomischer Anzeiger"},{"key":"e_1_2_9_18_1","first-page":"61","volume-title":"Verdauungsapparat","author":"Zimmermann K. 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