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Gut\u2010associated lymphoid tissue is the major immunological organization for the digestive system. Cecal tonsils are an important part of this organization. This study is a descriptive and experimental study that was conducted to determine the histological development of the cecal tonsils and the distribution of Toll\u2010like receptor (TLR) 2, TLR4 and antigen\u2010presenting cells during the first 2\u00a0weeks of the chick's life. The tissue sections were stained using Crossmon's triple technique, Gordon and Sweet's silver impregnation, and streptavidin\u2010biotin\u2010peroxidase complex methods. The classical tonsil framework with fossa and tonsillar units were observed in 4\u00a0days cecal tissue. The web of reticular fibres forming the stroma of the tissue had the impression that the lymphoid cells filling in time. The development of cecal tonsil was completed histologically on the day 10 and following day 14 samples. Regardless of the antigenic stimulation, TLR2, TLR4 and CD83, major histocompatibility complex (MHC) class II molecules are present in proximal cecal tissue. However, CD83\u2010positive dendritic cells in the germinal centre were first distinguished on day 7. Furthermore, the high antigen presentation capacity of the cecum with an intense MHC class II molecule expression was determined. Histological and immunohistochemical findings in this study revealed that both innate and adaptive cecal defence mechanisms were in the learning period during the first 2\u00a0weeks. The learning period of innate immunity may require more detailed research. However, the results obtained in this study will be taken into consideration in the vaccination programmes in chicks.<\/jats:p>","DOI":"10.1111\/ahe.12773","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T04:16:30Z","timestamp":1638764190000},"page":"125-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["TLR2 and TLR4 molecules and antigen\u2010presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post\u2010hatch period"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-8512","authenticated-orcid":false,"given":"Ulker","family":"Eren","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Faculty of Veterinary Medicine University of Aydin Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-4596","authenticated-orcid":false,"given":"Sadiye","family":"Kum","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Veterinary Medicine University of Aydin Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-4039","authenticated-orcid":false,"given":"Ahmet","family":"Nazligul","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Faculty of Veterinary Medicine University of Aydin Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-1706","authenticated-orcid":false,"given":"Ozay","family":"Gules","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Veterinary Medicine University of Afyon Kocatepe  Afyon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Aka","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Institute of Health Sciences University of Aydin Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-8947","authenticated-orcid":false,"given":"Mustafa","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Can School of Applied Sciences Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secil","family":"Zorlu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Institute of Health Sciences University of Aydin Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Temel \u0130mmunoloji","author":"Abbas A. 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