{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:33Z","timestamp":1747182933539,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008895","name":"Tertiary Education Trust Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphological development of the lamina epithelialis mucosae (LEM) of the ileum of broiler chicken was evaluated using light and transmission electron microscopic techniques. Ileal sections were collected on embryonic days (ED) 14, 17 and 19, as well as post\u2010hatch days (PD) 1, 3, 5, 7, 14, 21, 28, 35, 42 and 56. The result showed that the ileal LEM, which were poorly defined at embryonic days 14 and 17, consisted of enterocytes and some atypically shaped goblet cells. Apico\u2010lateral tight junctions and irregularly shaped microvilli were associated with the enterocytes at ED 14 and 17. The enterocyte microvilli were more uniform in shape and distribution at ED 19. The embryonic goblet cells were varied in shape and possessed basally displaced, star\u2010shaped nuclei and small apical cytoplasmic vacuoles. During the post\u2010hatch ages, the LEM was a typical epithelium with a single layer of columnar\u2010shaped enterocytes that became highly elongated at post\u2010hatch day (PD) 7. The goblet cells were characteristically \u2018wine\u2010glass\u2019 shaped. Follicle\u2010associated epithelium (FAE) showing numerous lymphocytes among the enterocytes occurred in the post\u2010hatch LEM. The intra\u2010epithelial lymphocytes (IEL) were first encountered at PD 1, but increased several folds within the first two weeks post\u2010hatch. Entero\u2010endocrine cells were observed in the epithelium from PD 21. Finally, from this study, it is obvious that enterocytes and small atypically shaped goblet cells occur in the ileal LEM during the pre\u2010hatch period, but these cells assume adult morphological characteristics after hatch. Thus, the cells of the ileal LEM play strategic absorptive, secretory and protective roles in the gut.<\/jats:p>","DOI":"10.1111\/ahe.12774","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T04:43:17Z","timestamp":1638938597000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Light and transmission electron microscopic evaluation of the lamina epithelialis mucosae in the ileum of pre\u2010 and post\u2010hatch broiler chicken"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-3886","authenticated-orcid":false,"given":"Anietie Francis","family":"Udoumoh","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy Faculty of Veterinary Medicine University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innocent Chima","family":"Nwaogu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Faculty of Veterinary Medicine University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udensi\u00a0Maduabuchi","family":"Igwebuike","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Faculty of Veterinary Medicine University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikechukwu Reginald","family":"Obidike","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology Faculty of Veterinary Medicine University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3721"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200393"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.32"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089881"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69505-6_1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001410407"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20554"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1993.Supplement_17.10"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010127"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.6.776"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.6.757"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2011.00767.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.046"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2014.11.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6716"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.044586"},{"volume-title":"Veterinary embryology","year":"2006","author":"McGeady T. 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