{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:41:14Z","timestamp":1768254074736,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Changes in the expression of nuclear \u03b2\u2010catenin are responsible for tumorigenesis. Beta\u2010catenin acts synergistically with the TGF\u2010\u03b2\/BMPs pathway. This interaction leads to greater dentin deposition and may explain the differences between distinct tooth morphologies and hamartomas. The aim of this study was to investigate the role of \u03b2\u2010catenin, BMP4 and TGF\u2010\u03b2 in the development of odontomas. This cross\u2010sectional, retrospective, immunohistochemical study evaluated 30 compound odontomas, 30 complex odontomas and 17 tooth germs. The results showed that BMP4 and TGF\u2010\u03b2 were more immunoexpressed in the ectomesenchyme of complex odontomas (median\u2009=\u200933.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; median\u2009=\u200976.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, respectively). Higher immunoexpression of BMP4 and TGF\u2010\u03b2 was also observed in the epithelium of tooth germs (median\u2009=\u20092.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; median\u2009=\u2009120.3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). TGF\u2010\u03b2 and BMP4 showed a positive and significant correlation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Both TGF\u2010\u03b2 and BMP4 were positively correlated with nuclear \u03b2\u2010catenin in ectomesenchyme (<jats:italic>p<\/jats:italic>\u2009=\u20090.047 and <jats:italic>p<\/jats:italic>\u2009=\u20090.023, respectively). Developing teeth exhibited higher concentrations of the proteins studied in odontogenic epithelium, especially during the bud and cap stages. Higher immunoexpression in odontomas occurred mainly in the ectomesenchyme. We therefore suggest that changes in the ectomesenchyme can lead to the development of odontomas.<\/jats:p>","DOI":"10.1111\/ahe.13024","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T07:04:45Z","timestamp":1709017485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunohistochemical expression of beta\u2010catenin, <scp>BMP4<\/scp> and <scp>TGF<\/scp>\u2010beta in odontomas"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-6601","authenticated-orcid":false,"given":"Gl\u00f3ria Maria","family":"de Fran\u00e7a","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9vila de Figueiredo","family":"Pires","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weslay Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"School of Dentistry, Postgraduate Program in Dentistry University of Pernambuco (UPE)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9verton Freitas","family":"de Morais","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseana de Almeida","family":"Freitas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia Batista","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9bel Cavalcanti","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601711010413"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12475"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12160"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476278.2019.1633871"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2018.009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211754"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199633"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010014\u20101241\u2010y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.1.173"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010020\u201001260\u2010x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23605"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.07.024"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.331"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22991"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2018.12.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3584751"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12494"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3716"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010021\u201001404\u20107"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14479"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010016\u20100459\u20100"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515583999"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12931"}],"container-title":["Anatomia, 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