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This study aimed to determine the embryotoxic and teratogenic effects of in\u2010ovo administered metamizole (dipyrone), which can be used when needed during pregnancy and has potent analgesic, antipyretic, anti\u2010inflammatory, and long bone (tibia and femur) effects. This study used 240 fertile eggs from Atak S breed chickens, divided into eight equal groups: control, vehicle control, and 15.62, 31.25, 62.5, 125, 250 and 500\u2009mg\/kg metamizole. The eggs were hatched on the 21st day of incubation, and the chicks' body weights and mortality rates were determined. The right and left femur and tibia bones were resected from the chicks. Anatomical reference points were determined after removing the soft tissues of the bones, and necessary morphometric measures were taken from these points with a 0.01\u2009mm precision using digital callipers. The 100% lethal dose (LD<jats:sub>100<\/jats:sub>) was identified in the highest examined dose (500\u2009mg\/kg) in the Chicken Embryotoxicity Screening Test (CHEST)\u2010I stage. The CHEST\u2010II stage determined the 50% lethal dose (LD<jats:sub>50<\/jats:sub>). High\u2010dose metamizole affected skeletal development, significantly decreasing tibia and femur lengths and corpus thicknesses and increasing mortality.<\/jats:p>","DOI":"10.1111\/ahe.13101","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T17:21:02Z","timestamp":1723483262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The embryotoxic and teratogenic effects of metamizole sodium"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-6849","authenticated-orcid":false,"given":"Selvinaz","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0368-4607","authenticated-orcid":false,"given":"Mustafa Orhun","family":"Dayan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"2542","article-title":"Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion","volume":"61","author":"Alexander F. 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