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In this study, we focused on <jats:styled-content style=\"fixed-case\"><jats:italic>Jaculus orientalis<\/jats:italic><\/jats:styled-content>, a desert\u2010adapted rodent that serves as an excellent model for investigating seasonal adaptation challenges. However, due to challenges in capturing and properly maintaining these animals in the laboratory, only a limited number of studies have been carried out so far. In this work, to explore the involvement of Dp in structural changes of the supraoptic nucleus (SON), accompanying seasonal adaptation in <jats:italic><jats:styled-content style=\"fixed-case\">Jaculus<\/jats:styled-content> orientalis<\/jats:italic>, first, we assessed the hydro\u2010osmotic state of wild <jats:styled-content style=\"fixed-case\"><jats:italic>Jaculus orientalis<\/jats:italic><\/jats:styled-content> during summer and winter; second, we analysed the histomorphometric changes of the SON; and third, we examined glial fibrillary acidic protein (GFAP) and Dp immunoreactivity across both seasons. Thirty eight males <jats:styled-content style=\"fixed-case\"><jats:italic>Jaculus orientalis<\/jats:italic><\/jats:styled-content> were used. The osmolality and the haematocrit were measured. Sections of the SON obtained were stained for histological study and immunohistochemistry for GFAP and Dps distribution analysis. Significant seasonal changes in osmolality, with stable haematocrit, demonstrate the ability of <jats:styled-content style=\"fixed-case\"><jats:italic>Jaculus orientalis<\/jats:italic><\/jats:styled-content> to modulate physiological parameters in response to seasonal conditions. The SON structure undergoes adaptive plasticity according to the seasons, suggesting intense SON stimulation during the arid summer, in contrast to the winter. Furthermore, immunohistochemical analysis showed a notable increase in Dp labeling in parallel with a marked reduction in GFAP signal in the SON soma during summer, and conversely, a decrease in Dp immunolabelling, with an increase in GFAP immunosignal in the SON soma during winter. Our findings reveal that seasonal changes in GFAP and Dp expressions, and the associated alterations in the neurovascular network activity within the SON, underline the role of Dp in structural plasticity mechanisms during osmotic adaptation in <jats:styled-content style=\"fixed-case\"><jats:italic>Jaculus orientalis<\/jats:italic><\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ahe.70054","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:30:27Z","timestamp":1753277427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dystrophins in Structural Changes of the Supraoptic Nucleus During Seasonal Adaptation in Wild <i>Jaculus orientalis<\/i>"],"prefix":"10.1111","volume":"54","author":[{"given":"Nadia","family":"Rouaiguia","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Laboratory of Biology and Physiology of Organisms, Neurochemistry Team USTHB 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