{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:13:21Z","timestamp":1778829201881,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vincristine, a microtubule\u2010disrupting vinca alkaloid, is teratogenic during organogenesis and may compromise neural crest\u2013related craniofacial development; however, its effects on craniofacial and cervical development and the potential for maternal L\u2010carnitine protection remain unclear. Pregnant New Zealand White rabbits (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099) were allocated to Group I\u2014Control (saline), Group II\u2014Vincristine (0.1\u2009mg\/kg intraperitoneally [IP] on gestational day [GD] 10) and Group III\u2014Vincristine + L\u2010carnitine (vincristine 0.1\u2009mg\/kg IP on GD 10 plus L\u2010carnitine 500\u2009mg\/kg IP on GD 9\u201314). Foetuses were collected at GD 29 for craniofacial and cervical morphometry, radiographic measurements and Alcian blue\/Alizarin red S skeletal staining. Compared with Group I controls, vincristine caused 36.7% embryonic resorption, universal craniofacial malformations, severe intrauterine growth retardation, 33%\u201385% reductions in craniofacial dimensions relative to control values, 29%\u201348% decreases in radiographic skull and mandibular measures and 22.8%\u201357.5% shortening of cervical metrics (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). With L\u2010carnitine co\u2010administration, resorption decreased to 13.3% and gross malformation burden was reduced; quantitatively, L\u2010carnitine recovered approximately 53%\u201378% of the vincristine\u2010induced craniofacial deficit, 65%\u2013100% of the radiographic skull and mandibular deficit and 71.5%\u201379% of the cervical shortening, although all measurements except rostral skull width remained significantly different from controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). These findings indicate that maternal L\u2010carnitine provides substantial, but incomplete, attenuation of vincristine\u2010associated craniofacial and cervical teratogenicity in the rabbit model.\n                  <\/jats:p>","DOI":"10.1111\/ahe.70120","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:51:57Z","timestamp":1777902717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vincristine\u2010Induced Craniofacial Skeletal Teratogenicity in Foetal Rabbits: Multimodal Morphometric Assessment and Partial Protection by L\u2010Carnitine"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0116-5723","authenticated-orcid":false,"given":"Alaa I. Abd","family":"El Latif","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Damanhour University  Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-1411","authenticated-orcid":false,"given":"Ashraf A.","family":"El Sharaby","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Damanhour University  Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman M.","family":"Hagras","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Public Health, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed G.","family":"Nomir","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Damanhour University  Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20107843.2006.00024.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci4010005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11536\u2010009\u20100021\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010205"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2020.1827319"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.26873\/SVR\u20102046\u20102024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141.3579.426"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201012\u20100091"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20107\u201030"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(00)00101\u20105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006227\u20108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2023.203899"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113551"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120209"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892\u20100362(92)90020\u2010B"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2020.105703"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/1519\u20106984.289225"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2011.03.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020307"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ahe.13053"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100722.2000.108005426.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.09.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174415001385"},{"key":"e_1_2_9_26_1","first-page":"703","article-title":"L\u2010Carnitine Protect Against Cyclophosphamide Induced Skeletal and Neural Tube Malformations in Rat Fetuses","volume":"53","author":"Mahabady M. 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