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Amylin\u2010immunoreactive cells were observed in pancreatic islets. These immunostaining profiles were not observed by the preabsorption of the anti\u2010amylin serum with synthetic amylin, indicating that the serum specifically recognized eel amylin\u2010like peptide. Almost all amylin\u2010immunoreactive cells were immunopositive for peptide YY, suggesting that amylin and peptide YY co\u2010secreted from the islet cells might participate in the modulation of insulin and glucagon secretion in the pancreatic islets. In addition, weakly glucagon\u2010immunopositive cells, but not densely glucagon\u2010immunopositive cells, also corresponded to amylin\u2010immunoreactive cells. The subpopulation of glucagon\u2010immunoreactive and glucagon\u2010like peptide\u20101\u2010immunoreactive cells was also immunopositive for peptide YY. These results suggest that amylin and peptide YY, and also presumably glucagon\u2010like peptide\u20101, are co\u2010secreted from the amylin\/peptide YY cells, and these three peptides modulate food intake through the central nervous system in addition to intrainsular functions.\n                  <\/jats:p>","DOI":"10.1111\/ahe.70161","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:17:58Z","timestamp":1786007878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amylin Coexisting With Peptide\n                    <scp>YY<\/scp>\n                    (\n                    <scp>PYY<\/scp>\n                    ) and Amylin\/\n                    <scp>PYY<\/scp>\n                    Cells Correspond to Subpopulations of Glucagon\u2010 and Glucagon\u2010Like Peptide\u20101\u2010Immunoreactive Cells in the Japanese Eel (\n                    <scp>\n                      <i>Anguilla japonica<\/i>\n                    <\/scp>\n                    ) Pancreas"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-6407","authenticated-orcid":false,"given":"Hirohumi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Biology University of Teacher Education Fukuoka  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medical Science Nagoya Aoi University  Nagoya Japan"},{"name":"Brain Functions and Neuroscience Unit, Department of Oral Science, Graduate School of Dentistry Kanagawa Dental University  Yokosuka 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