{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:04:10Z","timestamp":1789729450198,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62176268"],"award-info":[{"award-number":["62176268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Current understanding of the fascial structures within the human carotid sheath (CS) is largely based on static anatomical descriptions, with limited knowledge of their dynamic developmental process. This study aimed to characterise the developmental progression of the fascial architecture surrounding neurovascular components within the CS across four stages in the New Zealand White rabbit. Twenty New Zealand White rabbits were divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095 each): early foetal (Gestational Day 10), late foetal (Gestational Day 20), newborn (3\u2009days postnatal) and adult (3\u20134\u2009months). Whole transverse cervical sections were processed with H&amp;E staining and \u03b1\u2010SMA immunohistochemistry. In the rabbit, the common carotid artery, internal jugular vein and vagus nerve within the CS consistently exhibited a three\u2010layered fascial organisation comprising an inner fascial layer, an intermediate zone and an outer fascial layer. The arterial inner fascia showed the earliest onset and most pronounced thickening, forming a dense multilayered fibrous structure, while the venous and neural inner fasciae remained comparatively thin. This differential thickening pattern corresponds to the varying levels of intrinsic pulsatile haemodynamic stress among the three structures. The outer fascial layers of adjacent structures showed potential fusion, likely reflecting extrinsic mechanical interactions from surrounding tissues. This study demonstrates a consistent three\u2010layered fascial organisation within the CS across developmental stages, and these histomorphological findings are consistent with a possible role of dual mechanical influences in CS development.\n                  <\/jats:p>","DOI":"10.1111\/ahe.70170","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:25:05Z","timestamp":1787988305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Three\u2010Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1595-2300","authenticated-orcid":false,"given":"Han\u2010xiao","family":"Zhao","sequence":"first","affiliation":[{"name":"China\u2010Japan Friendship Institute of Clinical Medical Sciences  Beijing China"},{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010di","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Clinical Research Center for Medical Imaging in Hubei Province Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010li","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0797-4564","authenticated-orcid":false,"given":"Ming\u2010an","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073136"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020222"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wnsx.2023.100158"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj.84.49"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.09.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3896"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21089"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145207"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095\u20106433(02)00141\u20101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.14212"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102923.1977.tb00635.x"}],"container-title":["Anatomia, Histologia, Embryologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ahe.70170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ahe.70170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ahe.70170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:16:05Z","timestamp":1789726565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ahe.70170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ahe.70170"],"URL":"https:\/\/doi.org\/10.1111\/ahe.70170","archive":["Portico"],"relation":{},"ISSN":["0340-2096","1439-0264"],"issn-type":[{"value":"0340-2096","type":"print"},{"value":"1439-0264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"2026-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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